Protein tyrosine phosphatase control of metabolism / Kendra K. Bence, editor.

Format:

Book

Contributor:

Bence, Kendra K., editor.

Language:

English

Subjects (All):

Protein Tyrosine Phosphatases--metabolism.

Metabolic Diseases--enzymology.

Metabolism--physiology.

Protein-Tyrosine Kinases--metabolism.

Protein-tyrosine phosphatase--Metabolism--Regulation.

Protein-tyrosine phosphatase.

Metabolism.

Medical Subjects:

Protein Tyrosine Phosphatases--metabolism.

Metabolic Diseases--enzymology.

Metabolism--physiology.

Protein-Tyrosine Kinases--metabolism.

Physical Description:

xi, 273 pages : illustrations (some color) ; 24 cm

Place of Publication:

New York : Springer, [2013]

Summary:

Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes. Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism.

Contents:

Redox Regulation of PTPs in Metabolism: Focus on Assays / Yang Xu, Benjamin G. Neel

Quantitative Modeling Approaches for Understanding the Role of Phosphatases in Cell Signaling Regulation: Applications in Metabolism / Matthew J. Lazzara

Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism / Yannan Xi, Fawaz G. Haj

PTP1B and TCPTP in CNS Signaling and Energy Balance / Kendra K. Bence

PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress / Mirela Delibegovic, Nimesh Mody

Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling / Águeda González-Rodríguez

PTP1B in Obesity-Related Cardiovascular Function / Pimonrat Ketsawatsomkron

Role of the SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism / Maria I. Kontaridis

Metabolic Effects of Neural and Pancreatic Shp2 / Zhao He, Sharon S. Zhang

Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism / Ari Elson

The Role of LMPTP in the Metabolic Syndrome / Stephanie M. Stanford

Mitogen-Activated Protein Kinase Phosphatases in Metabolism / Ahmed Lawan, Anton M. Bennett

Glycogen Metabolism and Lafora Disease / Peter J. Roach.

Notes:

Includes bibliographical reference and index.

ISBN:

1461478545

9781461478546

OCLC:

841495275