Semiconducting silicon nanowires for biomedical applications / edited by Jeffrey L. Coffer.

Format:

Book

Contributor:

Coffer, Jeffery.

ScienceDirect (Online service)

Rosengarten Family Fund.

Series:

Woodhead Publishing series in biomaterials ; no.73.

Woodhead Publishing series in biomaterials

Language:

English

Subjects (All):

Nanowires.

Biomedical materials.

Physical Description:

1 online resource.

Place of Publication:

Cambridge : Woodhead Publishing, [2014]

System Details:

text file

Summary:

Biomedical applications have benefited greatly from the increasing interest and research into semiconducting silicon nanowires. Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and applications of this emerging material. After an introductory chapter providing an overview of semiconducting silicon nanowires for biomedical applications, Part I goes on to review the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires. Part II focus on silicon nanowires for tissue engineering and delivery applications including cellular binding and internalization, orthopedic tissue scaffolds, mediated differentiation of stem cells, and silicon nanoneedles for drug delivery. Finally, Part III highlights the use of silicon nanowires for detection and sensing. Chapters explore the fabrication and use of semiconducting silicon nanowire arrays for high-throughput screening in the biosciences, neural cell pinning on surfaces, and probe-free platforms for biosensing. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and tissue engineering and researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive biomaterials. Book jacket.

Contents:

Part I introduction to silicon nanowires for biomedical applications 1

1 Overview of semiconducting silicon nanowires for biomedical applications / J. L. Coffer, Texas Christian University, USA University, J. L. Coffer, Texas Christian, USA 3

1.1 Introduction 3

1.2 Origins of silicon nanowires 4

1.3 The structure of this book 4

1.4 Conclusion 6

1.5 References 7

2 Growth and characterization of semiconducting silicon nanowires for biomedical applications / Gengfeng Zheng Zheng, Gengfeng, Ming Xu, Fudan University, People's Republic of China China, Ming Xu, Fudan University, People's Republic of 8

2.1 Introduction 8

2.2 Synthesis methods for silicon nanowires (SiNWs) 9

2.3 Characterization methods 19

2.4 Synthesis of semiconductor SiNWs by the chemical vapor deposition (CVD) method 20

2.5 Conclusion 22

2.6 Future trends 22

2.7 Sources of further information and advice 23

2.8 References 24

3 Surface modification of semiconducting silicon nanowires for biosensing applications / Y. Coffinier Coffinier, Y., R. Boukherroub, CNRS and University of Lillel, France France, R. Boukherroub, CNRS and University of Lillel, 26

3.1 Introduction 26

3.2 Methods for fabricating silicon nanowires (SiNWs) 27

3.3 Chemical activation/passivation of SiNWs 27

3.4 Modification of native oxide layer 28

3.5 Modification of hydrogen-terminated silicon nanowires (H-SiNW) 41

3.6 Site-specific immobilization strategy of biomolecules on SiNWs 47

3.7 Control of non-specific interactions 50

3.8 Conclusion 52

3.9 References 52

4 Biocompatibility of semiconducting silicon nanowires / L. Marcon Marcon, L., R. Boukherroub, CNRS and University of Lillel, France France, R. Boukherroub, CNRS and University of Lillel, 62

4.1 Introduction 62

4.2 In vitro biocompatibility of silicon nanowires (SiNWs) 64

4.3 In vivo biocompatibility of SiNWs 74

4.4 Methodology issues 77

4.5 Future trends 79

4.6 Conclusion 82

4.7 References 83

Part II Silicon nanowires for tissue engineering and delivery applications 87

5 Functional semiconducting silicon nanowires for cellular binding and internalization / W. Zhang Zhang, W., C. Yang, Purdue University, USA University, C. Yang, Purdue, USA 89

5.1 Motivation: developing a nano-bio model system for rational design in nanomedicine 89

5.2 Methods: non-linear optical characterization and surface functionalization of silicon nanowires (SiNWs) 92

5.3 Applications: in vivo imaging and in vitro cellular interaction of functional SiNWs 96

5.4 Conclusions and future trends 99

5.5 References 99

6 Functional semiconducting silicon nanowires and their composites as orthopedic tissue scaffolds / J. L. Coffer, Texas Christian University, USA University, J. L. Coffer, Texas Christian, USA 104

6.1 Introduction 104

6.2 Nanowire surface etching processes to induce biomineralization 105

6.3 Nanowire surface functionalization strategies to induce biomineralization 107

6.4 Construction of silicon nanowire (SiNW)-polymer scaffolds: mimicking trabecular bone 110

6.5 The role of SiNW orientation in cellular attachment, proliferation and differentiation in the nanocomposite 112

6.6 Conclusions and future trends 116

6.7 Acknowledgement 116

6.8 References 116

7 Mediated differentiation of stem cells by engineered semiconducting silicon nanowires / T.-J. Yen Yen, T.-J., H.-I. Lin. National Tsing Hua University, Taiwan R. O. C. C., H.-I. Lin. National Tsing Hua University, Taiwan R. O. 118

7.1 Introduction 118

7.2 Methods for fabricating silicon nanowires (SiNWs) 123

7.3 Regulated differentiation for human mesenchymal stem cells (hMSCs) 126

7.4 SiNWs fabricated by the electroless metal deposition (EMD) method and their controllable spring constants 130

7.5 Mediated differentiation of stem cells by engineered SiNWs 135

7.6 Conclusion 138

7.7 Future trends 138

7.8 Acknowledgements 139

7.9 References 139

8 Silicon nanoneedles for drug delivery / C. Chiappini Chiappini, C., C. Almeida, Imperial College London, LIK London, C. Almeida, Imperial College, LIK 144

8.1 Introduction 144

8.2 Strategies for nanoneedle fabrication 147

8.3 Drug loading of nanoneedles and release patterns 151

8.4 Drug delivery using nanoneedles 154

8.5 Toxicity of nanoneedles 155

8.6 Overview of nanoneedle applications 156

8.7 Conclusion 162

8.8 References 163

Part III Silicon nanowires for detection and sensing 169

9 Semiconducting silicon nanowire array fabrication for high throughput screening in the biosciences / J. Wu, Georgia Southern University, USA University, J. Wu, Georgia Southern, USA 171

9.1 Introduction 171

9.2 Fabrication of silicon nanowire (SiNW) field effect transistor (FET) arrays for high throughput screening (HTS) in the biosciences 173

9.3 Surface modification of SiNW FETs for HTS in the biosciences 180

9.4 Integration of SiNW FETs with microfluidic devices for HTS in real-time measurements 181

9.5 Examples/applications of SiNW FETs 182

9.6 Conclusion 186

9.7 Future trends 186

9.8 References 187

10 Neural cell pinning on surfaces by semiconducting silicon nanowire arrays / C. Villard, Institut Néel, CNRS and Université Joseph Fourier, France France, C. Villard, Institut Néel, CNRS and Université Joseph Fourier, 192

10.1 Introduction 192

10.2 Toward control of neuronal topography and axo-dendritic polarity 193

10.3 Neuron networks on top of silicon nanowires (SiNWs) 203

10.4 Future trends 206

10.5 Conclusion 209

10.6 References 210

10.7 Appendix: experimental section. 212

11 Semiconducting silicon nanowires and nanowire composites for biosensing and therapy / E. Segal Segal, E., Y. Bussi, Technion, Israel Institute of Technology, Israel Israel, Y. Bussi, Technion, Israel Institute of Technology, 214

11.1 Introduction 214

11.2 Fabrication of silicon nanowires (SiNWs) and two-dimensional SiNW architectures 214

11.3 SiNWs for biosensing applications 216

11.4 Fabrication of SiNW-polymer composite systems 220

11.5 Biomedical applications of SiNW-polymer composites 222

11.6 Conclusions and future trends 224

11.7 References 225

12 Probe-free semiconducting silicon nanowire platforms for biosensing / A. De De, A., S. Chen, University of Twente, The Netherlands, E. T. Carlen, University of Tsukuba, Japan and University of Twente, The Netherlands 229

12.1 Introduction 229

12.2 Silicon nanowire (SiNW) biosensors 230

12.3 Probe layers 236

12.4 Integrated sample delivery 242

12.5 Electrical biasing and signal measurement 246

12.6 Examples/applications of SiNW biosensor platforms 248

12.7 Conclusions 256

12.8 Future trends 257

12.9 References 258.

Notes:

Electronic reproduction. Amsterdam Available via World Wide Web.

Description based on print version record.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

Other Format:

Print version:

ISBN:

1306459931

9781306459938

9780857097712

0857097717

Publisher Number:

99958581991

Access Restriction:

Restricted for use by site license.