Pattern formation in the cerebellum / Carol Armstrong, Richard Hawkes.

Format:

Book

Author/Creator:

Armstrong, Carol, 1969 December 10- author.

Hawkes, Richard, 1950- author.

Series:

Colloquium digital library of life sciences

Colloquium series on the developing brain ; 2159-5208 # 11.

Colloquium series on the developing brain, 2159-5208 ; # 11

Language:

English

Subjects (All):

Pattern formation (Biology).

Cerebellum--Differentiation.

Cerebellum.

Body Patterning.

Cerebellum--embryology.

Medical Subjects:

Body Patterning.

Cerebellum--embryology.

Physical Description:

1 online resource (xvii, 119 pages) : illustrations.

Place of Publication:

San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2014.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Pattern formation has fascinated biologists since the time of Aristotle, but only recently have new tools begun to reveal the underlying mechanisms that create these patterns during development. In particular, the central nervous system is dynamically patterned and highly modular, ranging from nuclear cell clusters in the brain stem and spinal cord to the elaborate cytoarchitecture of the neocortex. Similar developmental processes divide brain structures such as the cerebral cortex, basal ganglia, superior colliculus, and cerebellum into these sub-compartments. The way neural modules form and the mechanisms that establish connectivity between these modules is one of the most complex problems in neuroscience and also one of the most important. This monograph focuses on pattern formation in the developing cerebellum.

Contents:

List of figures

Sidebars

Tables

Abbreviations and glossary

1. Background and rationale

2. Overview of cerebellar organization

2.1 Cerebellar anatomy and terminology

2.2 Histology and cytology

2.2.1 Layers of the cerebellar cortex

2.2.2 Neurons of the cerebellar cortex

2.3 Cerebellar afferents and efferents

2.3.1 Cerebellar afferents

2.3.2 Cerebellar efferents, cerebellar nuclei, and the corticonuclear projection

2.4 Cerebellar circuitry

3. The modular cerebellum

3.1 Zones

3.2 Stripes

3.3 Patches

3.4 What is the topographical resolution of the cerebellar map?

4. Overview of cerebellar development

5. Establishment and organization of the cerebellar anlage

5.1 The boundaries of the cerebellar anlage

5.2 Products of the cerebellar anlage

5.2.1 Products of the 4th ventricle: specification of GABAergic neurons (purkinje cells and inhibitory interneurons)

5.2.2 Products of the rhombic lip: specification of glutamatergic neurons

5.2.3 The role of the rhombomere 1 roof plate

6. Development and patterning of purkinje cells

6.1 Purkinje cell genesis

6.1.1 Specification of purkinje cell subtypes

6.1.2 The role of engrailed in cerebellar development

6.2 The cluster map

6.2.1 Cluster formation and patterning

6.2.2 Cluster dispersal

6.2.3 Purkinje cell migration

6.3 From clusters to stripes

6.3.1 Stripe formation

6.3.2 Purkinje cell stripes and dendritogenesis

7. Development and patterning of granule cells

7.1 Formation of the external granular layer from the rhombic lip

7.2 Formation of the granular layer from the external granular layer

7.2.1 Proliferation in the external granular layer

7.2.2 Granule cell migration from the external granular layer to the granular layer

7.3 Patterning of the granular layer

7.3.1 Lineage restriction boundaries in the external granular layer and granular layer

7.3.2 Phenotype restriction boundaries in mutant mice

7.3.3 Gene expression domains in the granule cell layer

8. Development of afferent projections

8.1 Climbing fibers

8.1.1 Climbing fiber development and refinement

8.1.2 Establishment of climbing fiber topography

8.2 Mossy fibers

8.2.1 Mossy fiber development

8.2.2 Establishment of mossy fiber topography

9. Patterning of other cells in the cerebellum: inhibitory interneurons, unipolar brush cells, and glia

9.1 Origin and development of inhibitory interneurons

9.2 Patterning of inhibitory interneurons

9.2.1 Basket/stellate cell patterning

9.2.2 Golgi cell patterning

9.3 Origin and development of unipolar brush cells

9.4 Unipolar brush cell patterning

9.5 Origin and development of cerebellar glial cells

9.6 Glial cell patterning

10. Neuronal cell death in normal development

10.1 Programmed purkinje cell death in normal development

10.2 Patterned purkinje cell death

Conclusion/summary

References

Author biographies.

Notes:

Part of: Colloquium digital library of life sciences.

Title from PDF title page (viewed on November 14, 2013).

Series from website.

Includes bibliographical references (pages 83-118).

ISBN:

9781615044573

Access Restriction:

Restricted for use by site license.