Stroke : pathophysiology and therapy / Jens Minnerup and Antje Schmidt, Christiane Albert-Weissenberger and Christoph Kleinschnitz.

Format:

Book

Author/Creator:

Minnerup, Jens, author.

Schmidt, Antje, author.

Albert-Weissenberger, Christiane, author.

Kleinschnitz, Christoph, author.

Series:

Colloquium digital library of life sciences

Colloquium series on integrated systems physiology ; 2154-5626 # 42.

Colloquium series on integrated systems physiology, 2154-5626 ; # 42

Language:

English

Subjects (All):

Cerebrovascular disease.

Stroke.

Medical Subjects:

Stroke.

Physical Description:

1 online resource (viii, 91 pages) : illustrations.

Place of Publication:

San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies.

Contents:

1. Introduction

1.1 Stroke classifications

1.2 Epidemiology

1.3 Acute therapy

1.4 Prevention

2. Pathophysiology of acute injury

2.1 Excitotoxicity

2.2 Oxidative stress

2.2.1 Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases are important generators of ROS

2.2.2 Translational aspects

2.3 Inflammatory cascades

2.3.1 Detrimental effects of immune cell infiltration on ischemic brain injury

2.3.2 Beneficial effects of immune cell infiltration on ischemic brain injury

2.3.3 Translational aspects

2.4 Thrombus formation

2.4.1 Thrombus formation and its interrelationship with inflammation

2.4.2 The coagulation cascade as a novel target in stroke therapy

2.4.3 Inhibition of platelet function as a novel treatment strategy for stroke

2.5 Cerebral edema formation

2.5.1 Impact of aquaporin-4 (AQP4) on brain edema formation in ischemic brain injury

2.5.2 The impact of the KKS on brain edema formation in ischemic brain injury

3. Recovery and regeneration

3.1 Neurological impairment after stroke and spontaneous recovery

3.2 Neurogenesis

3.3 Angiogenesis and vasculogenesis

3.4 Axonal sprouting and dendritic plasticity

4. Future therapeutic strategies

4.1 Neuroprotection

4.1.1 Introduction

4.1.2 Translational failures of candidate neuroprotectants

4.1.3 Ongoing studies on neuroprotective drugs for ischemic stroke

4.1.4 Uric acid

4.1.5 Magnesium

4.1.6 Dapsone

4.1.7 Albumin

4.1.8 Ciclosporine

4.1.9 THR-18

4.1.10 PF-03049423

4.1.11 Combining neuroprotection with thrombolysis

4.1.12 Neuroprotection and hypothermia

4.1.13 Conclusions

4.2 Neurorestorative therapies

4.2.1 Mechanisms of spontaneous recovery as basis for future treatments

4.2.2 Growth factor treatment to enhance recovery after stroke

4.2.3 Counteracting inhibition of axonal sprouting

4.2.4 Cell therapy for stroke

4.3 Approaches to improve translation

References.

Notes:

Part of: Colloquium digital library of life sciences.

Title from PDF title page (viewed on September 20, 2013).

Series from website.

Includes bibliographical references (pages 55-91).

ISBN:

9781615045877

Access Restriction:

Restricted for use by site license.