Control of potassium : distribution, excretion, and extracellular concentration / David B. Young.

Format:

Book

Author/Creator:

Young, David B., author.

Series:

Colloquium digital library of life sciences

Colloquium series on integrated systems physiology ; 2154-5626 # 43.

Colloquium series on integrated systems physiology, 2154-5626 ; # 43

Language:

English

Subjects (All):

Potassium in the body.

Potassium--Metabolism--Regulation.

Potassium.

Potassium--metabolism.

Potassium--Metabolism.

Medical Subjects:

Potassium--metabolism.

Physical Description:

1 online resource (x, 93 pages) : illustrations.

Place of Publication:

San Rafael, California (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, 2013.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Several physiological mechanisms act to regulate renal potassium excretion and distribution. Together they comprise an integrated control system that may be envisioned as being made up of several interacting negative feedback control mechanisms, all affecting removal of potassium from the extracellular fluid by renal excretion or transfer across cell membranes into or out of the intracellular compartment. The intent of this presentation is to describe the mechanisms of potassium regulation, beginning in Chapter 1 with an overview of the system, Chapter 2 with mechanisms that determine movement of potassium between the extracellular and intracellular compartments, in Chapter 3 focusing on renal tubular transport systems, and in Chapter 4 presenting the mechanisms of control of aldosterone secretion. Greatest emphasis will be on describing the integrated functions of the components, in Chapter 5, as they operate together in a system to regulate extracellular potassium concentration in response to commonly encountered challenges. In addition, interactions between potassium regulation and commonly used medications will be considered in Chapter 6 , and in Chapter 7 the causes and treatment of dysregulation of potassium will be discussed.

Contents:

1. Introduction

2. Regulation of potassium distribution

2.1 Effect of sodium, potassium ATPase activity on distribution

2.2 Hormonal effects on distribution

2.3 Aldosterone's effect on distribution

2.4 Factors transiently affecting distribution

3. Potassium transport in segments of the nephron

3.1 Reabsorption in the proximate tubule

3.2 Reabsorption in the loop of Henle

3.3 Secretion and absorption in the distal nephron

4. Regulation of potassium excretion

4.1 Effect of tubular flow rate on reabsorption

4.2 Hormonal effects on reabsorption

4.2.1 Angiotensin II

4.2.2 Vasopressin

4.2.3 Prostaglandin E2

5. Control of aldosterone secretion

5.1 Cellular mechanisms of aldosterone secretion

5.2 Control of renin release

5.3 Long-term control of aldosterone

6. System analysis of potassium regulation

6.1 Tenets of the hypothesis

6.1.1 The mathematical model

6.2 Comparison of model simulations with experimental data

6.3 Model prediction

6.3.1 Clinically relevant model predictions

6.4 Questions raised by the model

6.5 Summary

7. Pharmacotherapeutics interactions

7.1 Diuretics

7.2 Inhibitors of angiotensin formation or receptor binding

7.3 Mineralocorticoid antagonists

7.4 Beta adrenergic receptor antagonists

7.5 Insulin

8. Disorders of potassium control

8.1 Hyperkalemia

8.2 Hypokalemia

8.2.1 Clinical symptoms

8.3 Etiology of potassium depletion and hypokalemia

8.3.1 Gastrointestinal loss

8.3.2 Loss in sweat

8.4 Diagnosis and treatment

8.4.1 Dietary modification

8.4.2 Potassium supplements

8.4.3 Potassium-sparing diuretics

8.5 Summary

References

Author bibliography.

Notes:

Part of: Colloquium digital library of life sciences.

Title from PDF title page (viewed on September 20, 2013).

Series from website.

Includes bibliographical references (pages 83-91).

ISBN:

9781615045013

Access Restriction:

Restricted for use by site license.