The actin cytoskeleton and the regulation of cell migration / Jonathan M. Lee.

Format:

Book

Author/Creator:

Lee, Jonathan M.

Series:

Colloquium digital library of life sciences

Colloquium series on building blocks of the cell ; 2328-305X # 5.

Colloquium series on building blocks of the cell, 2328-305X ; # 5

Language:

English

Subjects (All):

Actin.

Cytoskeleton.

Cell migration.

Actins.

Cell Movement.

Medical Subjects:

Actins.

Cytoskeleton.

Cell Movement.

Physical Description:

1 online resource (viii, 71 pages) : illustrations.

Place of Publication:

San Rafael, Calif. (1537 Fourth Street, San Rafael, CA 94901 USA) : Morgan & Claypool, [2013]

System Details:

Mode of access: World Wide Web.

text file

Summary:

The mammalian cytoskeleton is an internal framework of actin, tubulin, and intermediate filament proteins. Proteins of these three classes assemble non-covalently into filamentous polymers that support the structural integrity of the relatively fragile lipid plasma membrane. In addition, cytoskeletal polymers provide the mechanical strength that hold a cell together and anchor it to its growth substrate. The cytoskeleton must also have the capacity for rapid and substantial remodeling and provide the motive and tractor force necessary to drive motility. As such, the cytoskeleton has a functional duality: sufficiently rigid to prevent plasma membrane deformation but pliable enough to allow for cytokinesis; sufficiently adhesive to allow for traction but dynamic enough to allow movement from one place to another. A major research challenge in cytoskeleton biology is to understand how cytoskeletal proteins assemble and dissemble in support of physiological processes. This chapter will focus on the role of the actin cytoskeleton in cell migration. More specifically, we will focus on the actin cytoskeleton of vertebrate cells.

Contents:

1. Introduction

2. The fundamentals of actin polymerization

2.1 Actin structure

2.2 Polymerization and nucleation

2.3 Directionality and treadmilling

2.4 Actin and ATP

3. Accessory proteins regulate actin polymerization and assembly

3.1 Nucleation proteins

3.2 Bundling proteins

3.3 Capping proteins

3.4 Severing proteins

3.5 Contraction

4. Cellular actin structure

4.1 Visualizing the actin cytoskeleton

4.2 The cell cortex

4.3 The lamellipodium and lamella

4.4 Ruffles

4.5 Filopodia

4.6 Focal adhesions

4.7 Stress fibers

4.8 Podosomes

4.9 Pseudopodia

5. Cell migration

5.1 Randomness and directionality

5.2 Polarization

5.2.1 Rho family GTPases

5.2.2 Par polarity complexes

5.2.3 The phospholipids PI(3,4,5)P3 and PI(4,5)P2

5.3 Protrusion

5.3.1 Lamellipodial protrusion

5.4 Filopodial protrusion

5.5 Adhesion

5.6 De-adhesion and retraction

6. Summary of cell migration

References

Author biography.

Notes:

Part of: Colloquium digital library of life sciences.

Title from PDF t.p. (viewed on July 20, 2013).

Series from website.

Includes bibliographical references (pages 59-69).

Other Format:

Print version:

ISBN:

9781615043897

Access Restriction:

Restricted for use by site license.