Angiogenesis and Anti-Angiogenesis in Hematological Malignancies / by Domenico Ribatti.

Format:

Book

Author/Creator:

Ribatti, Domenico, 1956- author.

Contributor:

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Oncology.

Hematology.

Life sciences.

Physical Description:

1 online resource : illustration

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

It has been generally accepted that angiogenesis is involved in the pathogenesis of hematological malignancies, like acute and chronic leukemia, lymphoma, myelodysplastic syndromes, myeloproliferative neoplasms and multiple myeloma. The extent of angiogenesis in the bone marrow has been correlated with disease burden, prognosis and treatment outcome. Reciprocal positive and negative interactions between tumor cells and bone marrow stromal cells, namely hematopoietic stem cells, fibroblasts, osteoblasts/osteoclasts, endothelial cells, endothelial progenitor cells, T cells, macrophages and mast cells, mediated by an array of cytokines, receptors and adhesion molecules, modulate the angiogenic response in hematological tumors. More recently, it has been emphasized the pro-angiogenic role of the so called “vascular niche”, indicating a site rich in blood vessels where endothelial cells and mural cells such as pericytes and smooth muscle cells create a microenvironment that affects the behavior of several stem and progenitor cells, in hematological malignancies.

Contents:

Preface

Introduction

Angiogenesis in multiple myeloma

Angiogenesis in lymphomas

Angiogenesis in leukemia

Antiangiogenesis

Concluding remarks

References.

Other Format:

Printed edition:

ISBN:

9789401780353

Access Restriction:

Restricted for use by site license.