Heat Shock Proteins of Malaria / edited by Addmore Shonhai, Gregory L. Blatch.

Format:

Book

Author/Creator:

Shonhai, Addmore, editor.

Contributor:

Blatch, Gregory L., editor.

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Medical parasitology.

Emerging infectious diseases.

Biochemistry.

Physical Description:

1 online resource : illustration

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

This book describes the role of heat shock proteins in the life cycle of malaria parasites. The work includes a general introduction on the structural and functional features of heat shock proteins. The main focus is on the role of heat shock protein families from Plasmodium falciparum, their role in protein folding and in the development of malaria pathology. The functions of individual families of heat shock proteins from plasmodium species and their cooperation in functional networks is described. Subcellular and extracellular organelles such as the apicoplast and the Maurer's Clefts which are associated with plasmodium species, are discussed in detail. The role of heat shock proteins in the development and function of these organelles structures are highlighted. Although conceding that heat shock proteins may not be ideal antimalarial drug targets, prospects of targeting heat shock proteins in antimalarial drug discovery either directly and/or in combination therapies are explored.

Contents:

Introduction: The importance of molecular chaperones in survival and pathogenesis of the malaria parasite Plasmodium falciparum

General structural and functional features of molecular chaperones

The role of Hsp70s in the development and pathogenicity of Plasmodium species

Role of the Hsp40 family of proteins in the survival and pathogenesis of the malaria parasite

Role of Hsp90 in Plasmodium falciparum malaria

The role of parasite heat shock proteins in protein trafficking and host cell remodeling

Role of heat shock proteins in immune modulation in malaria

Establishment of Plasmodium falciparum extracellular compartments in its host erythrocyte

Chaperones and Proteases of Plasmodium falciparum

Heat shock proteins as targets for novel anti-malarial drugs

What do we know, what do we not know, and what should the future focus be?.

Other Format:

Printed edition:

ISBN:

9789400774384

Access Restriction:

Restricted for use by site license.