Proteins and Proteomics of Leishmania and Trypanosoma / edited by André L.S. Santos, Marta H. Branquinha, Claudia M. d'Avila-Levy, Lucimar F. Kneipp, Cátia L. Sodré.

Format:

Book

Author/Creator:

Santos, André L. S., editor.

Contributor:

Branquinha, Marta H., editor.

D'Avila-Levy, Claudia M., editor.

Kneipp, Lucimar F., editor.

Sodré, Cátia L., editor.

SpringerLink (Online service)

Series:

Sub-cellular biochemistry 0306-0225 ; 74.

Sub-cellular biochemistry

Language:

English

Subjects (All):

Medicine.

Medical parasitology.

Emerging infectious diseases.

Microbial genetics.

Physical Description:

1 online resource : illustration.

Contained In:

Springer eBooks

Place of Publication:

Dordrecht : Springer Netherlands : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids' genera are etiological agents of leishmaniasis, Chagas' disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteome of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.

Contents:

Preface

Biology of Human Pathogenic Trypanosomatids: Epidemiology, Lifecycle and Ultrastructure

Selection of Molecular Targets for Drug Development against Trypanosomatids

A2 and other visceralizing proteins of Leishmania: role in pathogenesis and application for vaccine development

Arginase in Leishmania

The heat shock proteins of Trypanosoma cruzi

The Gp82 Surface Molecule of Trypanosoma cruzi Metacyclic Forms

The Gp85 Surface Glycoproteins from Trypanosoma cruzi

Trypanosoma cruzi Trans-Sialidase: Structural Features and Biological Implications

Surface Topology Evolution of Trypanosoma Trans-Sialidase

Ecto-Nucleotidases and Ecto-Phosphatases from Leishmania and Trypanosoma Parasites

Gp63 Function in the Interaction of Trypanosomatids with the Invertebrate Host - Facts and Prospects

Highlights on Trypanosomatid Aminoacyl-tRNA Synthesis

The Expected Outcome of the Trypanosoma cruzi Proteomic Map: a Review of its Potential Biological Applications for Drug Target Discovery

Proteomics advances in the study of Leishmania parasites and leishmaniasis

Towards the Phosphoproteome of Trypanosomatids. Index.

Other Format:

Printed edition:

ISBN:

9789400773059

Access Restriction:

Restricted for use by site license.