MicroRNAs: Key Regulators of Oncogenesis / edited by Sadegh Babashah.

Format:

Book

Author/Creator:

Babashah, Sadegh, editor.

Contributor:

SpringerLink (Online service)

Language:

English

Subjects (All):

Medicine.

Oncology.

Human genetics.

Gene expression.

Medical genetics.

Drug interactions.

Physical Description:

1 online resource : illustration

Contained In:

Springer eBooks

Place of Publication:

Cham : Springer International Publishing : Imprint: Springer, 2014.

System Details:

Mode of access: World Wide Web.

text file PDF

Summary:

Aberrant expression and function of microRNAs (miRNAs) in cancer have added a new layer of complexity to the understanding of development and progression of the disease state. It has been demonstrated that miRNAs play a momentous role in oncogenesis via regulating cell proliferation and apoptosis as oncogenes or tumour suppressors. Expression signatures of miRNAs offer exciting opportunities for crafting cutting edge strategies in the diagnosis, prognosis, and therapy of cancer. Since miRNAs can function as either oncogenes or tumor suppressor genes in the tortuous route of oncogenesis, the promise represented by using these small RNAs as therapeutic targets presents new perspectives to the landscape of cancer therapy by either inhibiting or augmenting their activity. This book devotes efforts to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of miRNAs found to be associated with cancer pathogenesis and possible mechanisms underlying the substantial roles played by miRNAs in cancer development and progression. Also, it intends to pave the way for readers to gain novel insights into using miRNAs as cancer biomarkers and therapeutic platforms.

Contents:

Preface

Part I MicroRNAs: biology and implications in cancer

MicroRNAs and cancer: an overview

Epigenetics and microRNA in cancer

MicroRNA, diet and cancer chemoprevention

MicroRNAs and energy metabolism in cancer cells

MicroRNAs and solid tumors

MicroRNAs and blood cancers

MicroRNAs and oncogenic human viruses

MicroRNAs linking cancer and inflammation: focus on liver cancer

MicroRNAs and regulatory pathways in tumorigenesis

MicroRNA-modulated apoptotic and autophagic signaling networks in cancer

MicroRNAs and cancer drug resistance and drug sensitivity

The biological roles of microRNAs in cancer stem cells

Part II MicroRNAs and their clinical implications

MicroRNAs and clinical implications in cancer

MicroRNA expression profiling and its clinical impact in breast cancer

MicroRNAs and their clinical impact on resistance to anticancer treatment

Nanocarriers and microRNA-based scenarios for cancer therapy

Challenges and strategies for pulmonary delivery of microRNA-based therapeutics

Abbreviations

Index.

Other Format:

Printed edition:

ISBN:

9783319037257

Access Restriction:

Restricted for use by site license.