Multiple Sclerosis and Related Disorders / edited by Douglas S. Goodin.

Format:

Book

Contributor:

Goodin, Douglas S.

ScienceDirect (Online service)

Series:

Handbook of clinical neurology ; v.122.

Handbook of Clinical Neurology ; 122

Language:

English

Subjects (All):

Multiple sclerosis.

Multiple sclerosis--Treatment.

Neurology.

Genre:

Electronic books.

Physical Description:

1 online resource (734 pages).

Place of Publication:

Amsterdam : Elsevier Science, 2014.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology.

Contents:

Front Cover; Multiple Sclerosis and Related Disorders; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Pathogenesis; Chapter 1: Immune regulation of multiple sclerosis; Innate immune responses; Adaptive immune responses; The role of T cells in multiple sclerosis; The role of B cells in multiple sclerosis; Physiological B-cell biology; Autoreactive B cells; B cells in multiple sclerosis; Inflammatory mediators; Cytokines; Chemokines; Metalloproteinases; Termination of the immune response; References

Chapter 2: Pathology of Multiple Sclerosis and Related Inflammatory Demyelinating DiseasesGlobal Pathology of the Ms Brain and Spinal Cord; The Pathologic Spectrum of Demyelinated Plaques; Mri Correlates of Pathologically Identified Focal white-matter Lesions; Immunopathology of Active Focal white-matter Plaques; The Nature of the Inflammatory Response; The Relation Between Inflammation and Tissue Injury in Ms Lesions; Mechanisms of Brain Inflammation - what Attracts Inflammatory Cells Into Ms Plaques?; Inflammation and Blood-brain Barrier Damage in Ms are in Part Dissociated

Structural Features of Focal white-matter PlaquesMyelin and Oligodendrocyte Pathology; Remyelination; Axonal Injury and Destruction; Immunologic Mechanisms of Tissue Injury in Ms Lesions; Cytotoxic T Cells; Macrophage-mediated Tissue Injury; Oxidative Injury - Mitochondrial Dysfunction - Virtual Hypoxia; Antibody-mediated Demyelination And tissue destruction; Lesions Modified By Increased Susceptibility Of the Target Tissue; Blood-brain Barrier Leakage and Impaired Fibrinolysis in Ms Lesions May Augment Inflammation, Demyelination, and Axonal ...

Heterogeneity of MS Lesions: Interindividual Variation Or Stage Dependence? Cortical and Deep gray-matter Damage in Multiple Sclerosis; Cortical Demyelination; Cortical Atrophy; Involvement of Deep Gray Matter in the Brain and Spinal Cord; The normal-appearing White Matter in MS Is highly Abnormal; Pathology of Progressive Ms compared to relapsing-remitting MS; The Relation Between Multiple Sclerosis and Other Inflammatory Demyelinating Diseases; Devic's Neuromyelitis Optica: a Distinct Disease Entity

Balo's Disease is Part of the MS Spectrum, But involves Specific Additional Mechanisms of Tissue InjuryAcute Disseminated Encephalomyelitis; What Drives Inflammation in Ms: Autoimmunity, Infection, Or Neurodegeneration?; Autoimmunity; Infection; Neurodegeneration; Conclusions: the Pathologists view of Multiple Sclerosis; References; Chapter 3: The Good and the Bad of Neuroinflammation in Multiple Sclerosis; Introduction; A Brief Overview of Multiple sclerosis; The Immune Privilege of the Central Nervous System; Introduction; The Blood-brain Barrier; The Afferent Immunological Axis

Notes:

Description based upon print version of record.

The Efferent Immunological Axis

Other Format:

Print version: Goodin, Douglas S. Multiple Sclerosis and Related Disorders : Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab)

ISBN:

0444520015

9780444520012

9780444633095

044463309X

OCLC:

870587154

Access Restriction:

Restricted for use by site license.