Handbook of nanosafety : measurement, exposure and toxicology / Ulla Vogel...[and others].

Format:

Book

Contributor:

Vogel, Ulla, editor.

ScienceDirect (Online service)

Language:

English

Subjects (All):

Nanotechnology--Safety measures--Handbooks, manuals, etc.

Nanotechnology.

Nanostructured materials industry--Safety measures--Handbooks, manuals, etc.

Nanostructured materials industry.

Industrial safety.

Genre:

Electronic books.

Handbooks and manuals.

Physical Description:

1 online resource

Place of Publication:

London : Academic Press, [2014]

System Details:

Mode of access: World Wide Web.

text file

Summary:

Handbook of Nanosafety: Measurement, Exposure and Toxicology provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, this handbook demonstrates techniques to assess exposure and risks, and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the nanodevice initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment. Key Features, Written by leading researchers in the field of nanosafety. Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM), Develops strategies for Exposure Assessment, Risk Assessment and Risk Management, Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace Book jacket.

Contents:

1 General Introduction / Kai Savolainen Savolainen, Kai

1.1 Use and Applications of Engineered Nanomaterials 3

1.2 What is a Nanomaterial? 5

1.3 Exposure to Engineered Nanomaterials Merits Attention 6

1.4 How to Measure Exposure to Engineered Nanomaterials 8

1.5 How About the Hazards? 9

1.6 Requirements for the Assessment and Management of Risks of Engineered Nanomaterials 11

1.7 To Be Expected in the Future 12

1.8 Conclusions 12

References 13

2 Nanotechnology and Exposure Scenarios / Sheona A.K. Read Read, Sheona A.K., Araceli Sánchez Jiménez Jiménez, Araceli Sánchez, Bryony L. Ross Ross, Bryony L., Robert J. Aitken Aitken, Robert J., Martie Van Tongeren Tongeren, Martie Van

2.1 Introduction 17

2.2 Development of Nanotechnology 18

2.3 Production of Engineered Nanomaterials 19

2.4 Applications of Nanotechnology 20

2.5 Exposure Scenarios for Nanomaterials 28

2.6 Exposure Scenario Case Examples 36

2.7 Summary 55

Acknowledgements 55

References 55

3 Nanomaterials and Human Health / Harri Alenius Alenius, Harri, Julia Catalán Catalán, Julia, Hanna Lindberg Lindberg, Hanna, Hannu Norppa Norppa, Hannu, Jaana Palomäki Palomäki, Jaana, Kai Savolainen Savolainen, Kai

3.1 Introduction 59

3.2 Biokinetics, Cardiovascular and Neurotoxicity of Engineered Nanomaterials 66

3.3 Inflammatory Effects of Engineered Nanomaterials 75

3.4 Nanomaterial-Induced Pulmonary Inflammation 79

3.5 Nanomaterial-Induced Skin Inflammation 89

3.6 Genotoxicity of Engineered Nanomaterials 93

3.7 Carcinogenicity of Engineered Nanomaterials 110

3.8 Implications of Health Effects and Safety of Engineered Nanomaterials for Nanotechnologies 117

3.9 Conclusions 122

References 122

4 From Source to Dose: Emission, Transport, Aerosol Dynamics and Dose Assessment for Workplace Aerosol Exposure / Martin Seipenbusch Seipenbusch, Martin, Mingzhou Yu Yu, Mingzhou, Christof Asbach Asbach, Christof, Uwe Rating Rating, Uwe, Thomas A.J. Kuhlbusch Kuhlbusch, Thomas A.J., Göran Lidén Lidén, Göran

4.1 Sources of Nanoparticles in the Workplace (Seipenbusch) 135

4.2 Aerosol Dynamics in Workplace Atmospheres (Seipenbusch) 137

4.3 Modelling Approaches to Aerosol Dynamics and Transport in the Workplace (Yu) 141

4.4 Applications of Aerosol Dynamics and Flow Modelling to Workplace Exposure (Mingzhou Yu) 147

4.5 Modelling of the Evolution of a Nanoparticle Aerosol in a Simulated Workplace (Asbach, Rating, Kuhlbusch) 152

Acknowledgement 157

4.6 Dose Assessment (Lidén) 157

References 166

5 Monitoring and Sampling Strategy for (Manufactured) Nano Objects Agglomerates and Aggregates (NOAA): Potential Added Value of the NANODEVICE Project / Derk H. Brouwer Brouwer, Derk H., Göran Lidén Lidén, Göran, Christof Asbach Asbach, Christof, Markus G.M. Berges Berges, Markus G.M., Martie Van Tongeren Tongeren, Martie Van

5.1 Introduction 173

5.2 Measurement Principles and Instrumentation 176

5.3 Measurement Strategy 191

5.4 New Devices (Pre-Prototypes) Developed by NANODEVICE and Implications for Measurement Strategies 196

5.5 Conclusions 202

References 202

6 Quality Control of Measurement Devices - What Can Be Done to Guarantee High-Quality Measurements? / Hans-Georg Horn Horn, Hans-Georg, Dirk Dahmann Dahmann, Dirk, Christof Asbach Asbach, Christof

6.1 Responsibilities of the manufacturers (Horn) 207

6.2 Responsibilities of the Users (Dahmann) 213

6.3 External Instrument Comparison (Asbach) 216

References 221

7 Examples and Case Studies / Christof Asbach Asbach, Christof, Olivier Aguerre Aguerre, Olivier, Christophe Bressot Bressot, Christophe, Derk H. Brouwer Brouwer, Derk H., Udo Gommel Gommel, Udo, Boris Gorbunov Gorbunov, Boris, Olivier Le Bihan Bihan, Olivier Le, Keld Alstrup Jensen Jensen, Keld Alstrup, Heinz Kaminski Kaminski, Heinz, Markus Keller Keller, Markus, Ismo Kalevi Koponen Koponen, Ismo Kalevi, Thomas A.J. Kuhlbusch Kuhlbusch, Thomas A.J., Andre Lecloux Lecloux, Andre, Martin Morgeneyer Morgeneyer, Martin, Robert Muir Muir, Robert, Neeraj Shandilya Shandilya, Neeraj, Burkhard Stahlmecke Stahlmecke, Burkhard, Ana María Todea Todea, Ana María

7.1 Introduction 224

7.2 Emission Chambers, a Method for Nanosafety (Le Bihan, Morgeneyer, Shandilya, Aguerre, Bressot) 226

Acknowledgements 231

7.3 Exposure of Workers to Carbon Nanotubes in a Commercial Production Facility; Preliminary Results in the Frame of Risk Assessment and Risk Management (Lecloux, Gorbunov, Brouwer, Muir) 231

Acknowledgements 242

7.4 Investigations on CNT Release from Composite Materials During End of Life (Stahlmecke, Asbach, Todea, Kaminski, Kuhlbusch) 242

Acknowledgement 255

7.5 The Need for Speed: Detection and Characterization of Particle Release During Powder Handling Using On-line Monitors (Jensen, Koponen) 255

Acknowledgements 268

7.6 Particulate Emissions from Equipment Used in Ultra Clean Areas of the Semiconductor Industry (Gommel, Keller) 268

References 275

8 Risk Assessment and Risk Management / Markus G.M. Berges Berges, Markus G.M., Robert J. Aitken Aitken, Robert J., Sheona A.K. Read Read, Sheona A.K., Kai Savolainen Savolainen, Kai, Marita Luotamo Luotamo, Marita, Thomas Brock Brock, Thomas

8.1 Introduction 279

8.2 Basic Approaches to Control Exposure to Hazardous Substances / Thomas Brock Brock, Thomas 280

8.3 Hierarchy of Control 288

8.4 Excursus: Safe Handling of Nanomaterials in the Laboratory 296

8.5 Health Risk Management of Engineered Nanomaterials 300

8.6 Risk Governance, Policy Aspects and Legislation in the European Union and the United States 308

Disclaimer 320

Acknowledgement 320

References 320

9 Future Outlook of Engineered Nanomaterials and Nanotechnologies / Kai Savolainen Savolainen, Kai

9.1 Introduction 327

9.2 New Principles for Engineered Nanomaterials Risk and Safety Governance 330

9.3 Key Areas of Nanosafety Research and the Expected Achievements in These Research Areas 331

9.4 Future Health and Safety Requirements of Nanomaterials and Nanotechnologies and Identification of the Knowledge Needs and Gaps 331

9.5 The Complexity of Nanomaterials and Their Control and Regulation 333

9.6 Progress of Nanotechnologies on Safety Requirements of Nanomaterials and Technologies 333

9.7 Conclusions 335.

Notes:

Includes index.

Description based on print version record.

Other Format:

Print version:

ISBN:

1306213010

9781306213011

9780124166042

0124166040

OCLC:

866837849

Access Restriction:

Restricted for use by site license.