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Cured : how the Berlin patients defeated HIV and forever changed medical science / Nathalia Holt.
Van Pelt Library RA643.86.G2 H65 2014
Available
- Format:
- Book
- Author/Creator:
- Holt, Nathalia, 1980- author.
- Language:
- English
- Subjects (All):
- HIV infections--Treatment--Germany--Berlin.
- HIV infections.
- Gene therapy--Germany--Berlin--History.
- Gene therapy.
- HIV Infections--therapy.
- History.
- HIV infections--Treatment.
- Germany.
- Anti-HIV Agents--history.
- Anti-HIV Agents--therapeutic use.
- Genetic Therapy--history.
- History, 20th Century.
- History, 21st Century.
- Hydroxyurea--history.
- Hydroxyurea--therapeutic use.
- Treatment Outcome.
- Germany--Berlin.
- Medical Subjects:
- HIV Infections--therapy.
- Germany.
- Anti-HIV Agents--history.
- Anti-HIV Agents--therapeutic use.
- Genetic Therapy--history.
- History, 20th Century.
- History, 21st Century.
- Hydroxyurea--history.
- Hydroxyurea--therapeutic use.
- Treatment Outcome.
- Physical Description:
- xxi, 313 pages ; 24 cm
- Place of Publication:
- New York, New York : Dutton, [2014]
- Summary:
- A young molecular biologist at the forefront of HIV research, Nathalia Holt tells the historic, multilayered, and compassionate story of two patients--each known in medical literature as the Berlin Patient--and their young research-minded doctors. The backdrop is nothing less than a revolution in cultural attitudes and medical thinking. These two patients' disparate cures came twelve years apart: the first in 1996 from an experimental cancer drug, the other in 2008 from a bone marrow transplant of cells with a particular genetic mutation. Holt connects the molecular dots of these two cases for the first time, providing insight into one of the most important medical breakthroughs of our generation.--From publisher description.
- Contents:
- Part I A Doctor, Two Patients, and Some Tests
- Chapter 1 The Good Doctor in Denial 3
- Chapter 2 A Visit with the Family Doctor 13
- Chapter 3 Death Sentence? 21
- Part II The Disease, a Drug, and Its Industry
- Chapter 4 Viral Trojan Horse 33
- Chapter 5 A Weapon from the War on Cancer 43
- Chapter 6 The Days of Acting Up 57
- Chapter 7 Recognizing a Global Pandemic 65
- Chapter 8 From the One Percent 79
- Chapter 9 But, Doctor, I Don't Feel Sick 87
- Chapter 10 The Delta 32 Mutation 95
- Chapter 11 Calling All Elite Controllers 99
- Chapter 12 Treatment in Hiding 111
- Part III Treating the Berlin Patients
- Chapter 13 The Second Diagnosis 119
- Chapter 14 The Compassionate Use Exemption 131
- Chapter 15 Three Deadly Diseases Move In 135
- Chapter 16 The Comfort of Family and Strangers 141
- Chapter 17 Timing 147
- Chapter 18 Transplanting 153
- Chapter 19 "Perhaps We Have Eradicated HIV" 163
- Chapter 20 An Unexciting Recovery 175
- Part IV The Cure
- Chapter 21 Trials 185
- Chapter 22 Proof of Principle 199
- Chapter 23 The Good Doctor in Court 205
- Chapter 24 Not Even Surprising 209
- Chapter 25 The Promise Kept 221
- Chapter 26 A Child Cured-So What? 241
- Chapter 27 Zinc Finger Snap 249
- Chapter 28 The Abused, the Respected, the Relentless 261.
- Notes:
- Includes bibliographical references (pages 273-295) and index.
- ISBN:
- 9780525953920
- 0525953922
- OCLC:
- 858649761
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