Mouse models of cancer : a laboratory manual / edited by Cory Abate-Shen, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, Columbia University Medical Center, Katerina Politi, Yale Cancer Center, Yale University School of Medicine, Lewis A. Chodosh, Perelman School of Medicine, University of Pennsylvania, Kenneth P. Olive, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, Columbia University Medical Center.

Format:

Book

Contributor:

Abate-Shen, Cory.

Politi, Katerina.

Chodosh, Lewis A.

Olive, Kenneth P.

Language:

English

Subjects (All):

Cancer--Animal models.

Cancer.

Mice--Diseases--Pathophysiology.

Mice.

Mice as laboratory animals.

Neoplasms--genetics.

Mice--Diseases.

Physiology, Pathological.

Disease Models, Animal.

Models, Genetic.

Neoplasms, Experimental.

Medical Subjects:

Neoplasms--genetics.

Disease Models, Animal.

Mice.

Models, Genetic.

Neoplasms, Experimental.

Genre:

Laboratory manuals.

Physical Description:

xiv, 521 pages : illustrations (some color) ; 28cm

Place of Publication:

Cold spring Harbor, New York : Cold Spring Harbor Laboratory Press, [2014]

Summary:

"The laboratory mouse is an important model for studying cancer and its treatment. This book includes both background information and step-by-step protocols for generating mouse models that accurately recapitulate many features of human cancer. It covers genetic models, including transgenic germline models, gene knockouts and knockins, and conditional and inducible systems, as well as models derived using chemical carcinogens, RNA interference, tissue recombination, and other strategies. Techniques to characterize tumor development, progression, and metastasis in these mice using state-of-the-art imaging, histopathological, surgical, and other approaches are described. The uses of these models in preclinical and translational research are also discussed"-- Provided by publisher.

"99% of mouse protein-coding genes have an equivalent homolog in the human genome, despite the striking differences in appearance between mouse and man. This remarkable genetic similarity, together with our ability to finely engineer the murine genome, has made the mouse the ideal animal in which to model and analyze human biology and disease. This book envisages the next generation of mouse models, and it also addresses the strategic use of mice in the fight against cancer"-- Provided by publisher.

Notes:

Includes bibliographical references and index.

ISBN:

9781621820031

1621820033

9781621820048

1621820041

OCLC:

854980461