Engineering polymer systems for improved drug delivery / edited by Rebecca A. Bader, David A. Putnam.

Format:

Book

Contributor:

Bader, Rebecca A., 1977- editor.

Putnam, David A., 1966- editor.

ebrary, Inc.

Language:

English

Subjects (All):

Polymeric drug delivery systems.

Polymeric drugs.

Polymers in medicine.

Drug delivery systems.

Physical Description:

1 online resource ( xvi, 474 pages.)

Place of Publication:

Hoboken, New Jersey : John Wiley & Sons, Inc., [2014]

System Details:

text file

Summary:

High-throughput technology has dramatically increased the pace of new drug development; however, negative side effects remain a significant problem in the field, hampering our ability to bring safe and effective drugs to market. Drawing from the latest advances in pharmaceutical science and polymer engineering, this text explains the role of polymers in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of therapeutics. As a result, readers will learn how to maximize the potential of therapeutics, including those previously eliminated as viable candidates due to undesirable interactions. Engineering Polymer Systems for Improved Drug Delivery features contributions from a team of leading experts and pioneers in the field. The text begins with an exploration of the fundamentals and challenges of drug delivery, setting a solid foundation for the text's core topics: Injectable polymeric drug delivery systems, Implantable polymeric drug delivery systems, Oral polymeric drug delivery systems, Advanced polymeric drug delivery Each chapter covers the basics to engage novice investigators and students as well as more advanced topics to support experienced researchers. Worked examples in every chapter help readers better understand the ins and outs of designing successful polymeric drug delivery systems. There are also practice problems that challenge readers to apply their newfound knowledge. With its systematic and logical approach, Engineering Polymer Systems for Improved Drug Delivery is recommended both as a textbook for courses in pharmaceutical science and drug delivery as well as a reference for professionals in drug delivery. Book jacket.

Contents:

Part I Introduction 1

1 Fundamentals of Drug Delivery / Rebecca A. Bader Bader, Rebecca A. 3

1.1 Introduction: History and Future of Drug Delivery 3

1.2 Terminology 5

1.3 Basic Pharmacokinetics 8

1.4 Basic Pharmacodynamics 12

1.5 Mass Transfer 13

1.6 Key Points 23

1.7 Homework Problems 23

2 Challenges of Drug Delivery / Patricia R. Wardwell Wardwell, Patricia R., Rebecca A. Bader Bader, Rebecca A. 29

2.1 Introduction 29

2.2 History and Challenges of Drug Delivery 30

2.3 Physical Barriers 31

2.4 Metabolic and Chemical Concerns 39

2.5 Physical Properties of Therapeutics 42

2.6 Polymer Carriers as a Solution to Challenges 45

2.7 Key Points 50

2.8 Homework Problems 50

Part II Injectable Polymeric Drug Delivery Systems 55

3 Polymer-Drug Conjugates / Cristina Fante Fante, Cristina, Francesca Greco Greco, Francesca 57

3.1 Introduction 57

3.2 Historical Perspective 58

3.3 Polymer-Drug Conjugates: Biological Rationale 59

3.4 Structural Features of Polymer-Drug Conjugates 62

3.5 Making a Polymer-Drug Conjugate 68

3.6 Current Challenges and Future Perspectives 71

3.7 Key Points 75

3.8 Worked Example 76

3.9 Homework Problems 76

4 Polymeric Microparticles / Noelle K. Comolli Comolli, Noelle K., Colleen E. Clark Clark, Colleen E. 85

4.1 Introduction 85

4.2 The Rationale for Microparticles 86

4.3 Defining the Design Criteria 87

4.4 Polymer Selection 89

4.5 Microparticle Synthesis 91

4.6 Microparticle Characterization Methods 96

4.7 Drug Release from Microparticles 100

4.8 Microparticle Design Examples 108

4.9 Key Points 110

4.10 Worked Example 110

4.11 Homework Problems 111

5 Polymeric Nanoparticles / Andrew L. Vasilakes Vasilakes, Andrew L., Thomas D. Dziubla Dziubla, Thomas D., Paritosh P. Wattamwar Wattamwar, Paritosh P. 117

5.1 Introduction 117

5.2 PNP Design 124

5.3 PNP Formulation Methods and Targeting 128

5.4 Nanoparticle Targeting Overview 133

5.5 PNP Characterization 139

5.6 Major Clinical Achievements 147

5.7 Key Points 148

5.8 Worked Example 149

5.9 Homework Problems 150

6 Block Copolymer Micelles and Vesicles for Drug Delivery / James D. Robertson Robertson, James D., Nisa Patikammonthon Patikammonthon, Nisa, Adrian S. Joseph Joseph, Adrian S., Giuseppe Battaglia Battaglia, Giuseppe 163

6.1 Introduction 163

6.2 Drug Encapsulation and Release 165

6.3 Bioavailability and Biodistribution 166

6.4 Stimuli Responsiveness 170

6.5 The Immune System 174

6.6 Gene Therapy 177

6.7 Cancer Therapy 180

6.8 Conclusions 182

6.9 Key Points 182

6.10 Homework Problems 183

Part III Implantable Polymeric Drug Delivery Systems 189

7 Implantable Drug Delivery Systems / Luis Solorio Solorio, Luis, Angela Carlson Carlson, Angela, Haoyan Zhou Zhou, Haoyan, Agata A. Exner Exner, Agata A. 191

7.1 Introduction 191

7.2 Nondegradable Polymeric Implants 193

7.3 Biodegradable Polymeric Implants 198

7.4 Conclusions and Future Perspectives 215

7.5 Key Points 216

7.6 Homework Problems 216

8 Polymeric Drug Delivery Systems in Tissue Engineering / Matthew Skiles Skiles, Matthew, James Blanchette Blanchette, James 227

8.1 Introduction 227

8.2 Wound Healing as a Prototype for Adult Tissue Generation 228

8.3 Bioactive Factors in Tissue Engineering and Regenerative Medicine 232

8.4 Delivery of Growth Factors in Tissue Engineering and Regenerative Medicine 248

8.5 Key Points 268

8.6 Worked Example 269

8.7 Homework Problems 270

Part IV Oral Polymeric Drug Delivery Systems 283

9 Oral Controlled-Release Polymeric Drug Delivery Systems / James W. McGinity McGinity, James W., James C. DiNunzio DiNunzio, James C., Justin M. Keen Keen, Justin M. 285

9.1 Introduction 285

9.2 Release Mechanisms of Oral Polymeric Dosage Forms 288

9.3 Oral Polymeric Release Modifiers 295

9.4 Manufacturing Technologies and Industrial Applications of Controlled Release 297

9.5 Worked Example 311

9.6 Key Points 314

9.7 Homework Problems 314

10 Mucoadhesive Drug Delivery Systems / Srinath Muppalaneni Muppalaneni, Srinath, David Mastropietro Mastropietro, David, Hossein Omidian Omidian, Hossein 319

10.1 Introduction 319

10.2 Factors Affecting Mucoadhesion 320

10.3 Polymer-Mucus Interactions 320

10.4 Mucoadhesion Mechanisms 322

10.5 Mucoadhesive Polymers 324

10.6 Novel Mucoadhesive Materials 327

10.7 Mucoadhesion Testing 330

10.8 Drug Release Studies 332

10.9 Mucoadhesive Dosage Forms 332

10.10 Conclusion 334

10.11 Key Points 334

10.12 Homework Questions 337

11 Enhanced Oral Drug Delivery Through Metabolic Pathways / Gregory Russell-Jones Russell-Jones, Gregory 343

11.1 Introduction 343

11.2 Uptake of Nutrients from the Intestine 344

11.3 Nutrient Transport in the Intestine 349

11.4 Use of Nutrient Transporters for Drug Delivery 352

11.5 Case Study: The Use of the Vitamin B₂ Uptake System for Drug Delivery 352

11.6 Key Points 365

11.7 Worked Example 365

11.8 Homework Problems 366

Part V Advanced Polymeric Drug Delivery 375

12 Stimuli-Responsive Polymer Delivery Systems / Amy Van Hove Hove, Amy Van, Zhanwu Cui Cui, Zhanwu, Danielle S. W. Benoit Benoit, Danielle S. W. 377

12.1 Introduction 377

12.2 Temperature-Responsive Polymers for Drug Delivery 378

12.3 pH-Responsive Polymers for Drug Delivery 387

12.4 Reduction/Oxidation (Redox)-Responsive Polymers 397

12.5 Enzymatically Responsive Drug Delivery 403

12.6 Key Points 415

12.7 Homework Questions 416

13 Affinity-Based Drug Delivery / Andrew S. Fu Fu, Andrew S., Horst A. von Recum Recum, Horst A. von 429

13.1 Introduction 429

13.2 Association Constant 430

13.3 Worked Example 432

13.4 Affinity-Based Drug Delivery Systems 437

13.5 Mathematical Modeling of Affinity-Based Systems 444

13.6 Challenges and Future Directions 448

13.7 Key Points 448

13.8 Homework Problems 449.

Notes:

Includes bibliographical references and index.

Electronic reproduction. Palo Alto, Calif. Available via World Wide Web.

Description based on online resource; title from digital title page (viewed on Feb. 27, 2014).

Other Format:

Print version: Engineering polymer systems for improved drug delivery

ISBN:

9781118747896

9781118747728

1118747720

1118747895

Access Restriction:

Restricted for use by site license. Single-user access only.