The HDL handbook : biological functions and clinical implications / edited by Tsugikazu Komoda.

Format:

Book

Contributor:

Komoda, Tsugikazu, editor.

ScienceDirect (Online service)

Language:

English

Subjects (All):

High density lipoproteins--Physiological effect.

High density lipoproteins.

High density lipoproteins--Metabolism.

Cholesterol, HDL.

Medical Subjects:

Cholesterol, HDL.

Genre:

Electronic books.

Physical Description:

1 online resource

Edition:

Second edition.

Place of Publication:

London : Academic Press, [2014]

System Details:

Mode of access: World Wide Web.

text file

Summary:

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol. Provides bench-to-bedside coverage of HDL with thorough coverage of basic science, genetics, epidemiology, and treatment. Presents a complete update with six new chapters on the latest advances in HDL cholesterol research with international perspective. New chapters on proteomics, clinical impact of LCAT in HDL metabolism, and an in-depth discussion of potential targets to modify HDL provide a translational reference for clinicians.

Contents:

1 Introduction of HDL Molecules, Past and Brief Future / Mari Tabuchi Tabuchi, Mari, Tsugikazu Komoda Komoda, Tsugikazu 1

1 Introduction 1

2 HDL May be an Independent Predictor of CHD 3

3 High Levels of HDL Sometimes Cause Atherosclerosis: the Example of CETP Deficiency 3

4 Is HDL-C Really "Good Cholesterol"? 4

5 Quantitative and Qualitative Measurement of HDL-C Molecules 4

6 Conclusion 5

References 5

2 Apolipoprotein A-I Mutations and Clinical Evaluation / Akira Matsunaga Matsunaga, Akira 9

1 Introduction 10

2 Physiological Functions of apoA-I 10

3 Genomic and Protein Structure of apoA-I 12

4 ApoA-I Deficiencies with Large Deficiency, Inversion, Nonsense, Frameshift Mutations 14

5 ApoA-I Missense Mutations with Low HDL-C 18

6 ApoA-I Mutations Related to Amyloidosis 21

7 Cysteine Mutants of apoA-I 26

8 Anti-Atherogenic apoA-I and apoA-I_Milano 27

9 Conclusion 28

References 28

3 The Complexity of High-Density Lipoproteins / Bela F. Asztalos Asztalos, Bela F., MarikoTani, Brian Ishida Ishida, Brian 37

1 HDL and Cardiovascular Disease 38

2 What is HDL? 38

3 HDL Metabolism 39

4 Moderators of HDL Particle Distribution and Composition 46

5 HDL Structure 47

6 HDL Proteomics 48

7 HDL Functions 51

8 The Future of HDL Research 57

References 53

4 Reverse Cholesterol Transport in HDL Metabolism: Modulation of Structural and Functional Features of HDL Particles / Elise F. Villard Villard, Elise F., Maryse Guerin Guerin, Maryse 65

1 Overall Mechanism of the Reverse Cholesterol Transport 66

2 Relationship Between HDL Structure and Function in Reverse Cholesterol Transport 53

3 Metabolic Disorders Associated with a Low HDL-C Phenotype and Dysfunctional HDL Particles 75

4 Inflammatory States Associated with Altered HDL Function in Reverse Cholesterol Transport 82

5 Genetic Variants Associated with Altered HDL Function in Reverse Cholesterol Transport 84

6 Conclusion 92

References 92

5 Role of ATP-Binding Cassette Transporters A1 and G1 in Reverse Cholesterol Transport and Atherosclerosis / Makoto Ayaori Ayaori, Makoto, Katsunori Ikewaki Ikewaki, Katsunori 103

1 Introduction 104

2 The Role of Reverse Cholesterol Transport in Lipid Metabolism 104

3 Major Pathways for Cellular Cholesterol Efflux 106

4 Mechanisms for Cholesterol Efflux and Generation of Nascent HDL: Role of ABCA1 107

5 Mechanisms for Maturation of HDL Particles and Maintenance of Circulating HDL Levels: Role of ABCA1 108

6 The Role of ABCG1 in Cholesterol Efflux and HDL Metabolism 110

7 Transcriptional Regulation of ABCA1/G1 111

8 Posttranscriptional/Posttranslational Regulation of ABCA1/G1 114

9 The Role of ABCA1/G1 in Reverse Cholesterol Transport and Atherosclerosis in Animal Models 116

10 The Role of ABCA1/G1 in Atherosclerosis in Humans 119

11 Therapeutic Strategies Against Atherosclerosis Involving RCT Modification 120

12 Conclusion 122

References 123

6 Sphingolipids and HDL Metabolism / Xian-Cheng Jiang Jiang, Xian-Cheng, Zhiqiang Li Li, Zhiqiang, Amirfarbod Yazdanyar Yazdanyar, Amirfarbod 133

1 Introduction 134

2 Plasma HDL-SM Origination 134

3 Sphingolipid De Novo Synthesis and HDL Metabolism 139

4 Plasma SM and HDL Metabolism 144

5 Plasma S1P and HDL Metabolism 145

6 Plasma Membrane Sphingolipid Levels and Cholesterol Efflux 145

7 Sphingolipids and Atherosclerosis 146

8 Conclusion 148

References 149

7 Role of Lecithin: Cholesterol Acyltransferase in HDL Metabolism and Atherosclerosis / Lusana Ahsan Ahsan, Lusana, Alice F. Ossoli Ossoli, Alice F., Lita Freeman Freeman, Lita, Boris Vaisman Vaisman, Boris, Marcelo J. Amar Amar, Marcelo J., Robert D. Shamburek Shamburek, Robert D., Alan T. Remaley Remaley, Alan T. 159

1 Introduction 160

2 LCAT Biochemistry 160

3 The Role of LCAT on Reverse Cholesterol Transport 167

4 Familial LCAT Deficiency and Fish-Eye Disease: Clinical Signs and Symptoms 170

5 Animal Models Exploring the Functional Role of LCAT 174

6 LCAT and its Role in Atherosclerosis in Human Studies 178

7 LCAT-Based Therapies 185

8 Conclusion 186

References 187

8 Cholesteryl Ester Transfer Protein Inhibitors: A Hope Remains / Akihiro lnazu lnazu, Akihiro 195

1 Introduction 196

2 HDL-TG as a Key Component Determining Neutral Lipid Transfer 196

3 HDL Metabolism in CETP Deficiency 198

4 LDL Metabolism in CETP Deficiency 199

5 VLDL Metabolism in CETP Deficiency 200

6 Antioxidant Activity in CETP Deficiency 200

7 Difference of Lipoprotein Phenotype Between Homozygotes and Heterozygotes with CETP Deficiency 201

8 Source of CETP and Cholesteryl Ester Transfer (CET) Determinant 202

9 Drug Designs in Clinical Trials 204

10 Structural Difference of CETP Inhibitors in the Cavity of CETP 207

11 Differential Effects Among CETP Inhibitors 208

12 Perspective of CETP Inhibitor 211

13 Conclusion 213

References 213

9 HDL Apoprotein Mimetic Peptides as Anti-Inflammatory Molecules / Godfrey S. Getz Getz, Godfrey S., Catherine A. Reardon Reardon, Catherine A. 221

1 Introduction 222

2 ApoA-l and the History of its Derived Mimetic Peptides 224

3 Anti-Atherogenic Effects of apoA-l Mimetic Peptides 227

4 Anti-Inflammatory Properties of apoA-l Mimetic Peptides with Cells in Culture 229

5 In Vivo Anti-Inflammatory Properties of apoA-l-Derived Mimetic Peptides 234

6 Hybrid and apoE Mimetics 237

7 Conclusion 240

References 241

10 Oxidized High-Density Lipoprotein: Friend or Foe / Toshiyuki Matsunaga Matsunaga, Toshiyuki, Akira Hara Hara, Akira, Tsugikazu Komoda Komoda, Tsugikazu 247

1 Introduction 248

2 Clinical Relevance of oxHDL to Vascular-Related Diseases 249

3 Structural Alterations in HDL Components by Oxidation 252

4 Functional Alterations in HDL by Oxidation 255

5 Is oxHDL Friend or Foe? 260

6 Conclusion 263

References 264

11 Current Aspects of Paraoxonase-1 Research / Mike Mackness Mackness, Mike, Bharti Mackness Mackness, Bharti 273

1 Introduction 274

2 PON1 and Atherosclerosis 275

3 Dysfunctional HDL 280

4 PON1 and Other Inflammatory Diseases 281

5 PON1 and Organophosphate Toxicity 281

6 PON1 and Cancer 283

7 PON1 and Quorum Quenching 283

8 PON1 and Aging 284

9 Conclusion 284

References 285

12 Proteomic Diversity in HDL: A Driving Force for Particle Function and Target for Therapeutic Intervention / Scott M. Gordon Gordon, Scott M. 293

1 Introduction to HDL-Associated Proteins 295

2 The Proteomic Diversity of HDL 298

3 Proteomic Subspeciation of HDL 306

4 Influence of Disease on the HDL Proteome 310

5 HDL Proteins as Therapeutic Targets 312

6 Challenges of MS-Based Analyses of the HDL Proteome 315

7 Conclusion 316

References 317.

Notes:

Description based on print version record.

Previous edition: London: Elsevier, 2010.

Includes bibliographical references and index.

OCLC:

862961383

Access Restriction:

Restricted for use by site license.