Amino acids in human nutrition and health / edited by J.P.F. D'Mello.

Format:

Book

Contributor:

C.A.B. International.

D'Mello, J. P. Felix.

Language:

English

Subjects (All):

Amino acids in human nutrition.

Amino acids--Metabolism.

Amino acids.

Amino Acids--metabolism.

Amino Acids--therapeutic use.

Enzymes--metabolism.

Enzyme Therapy.

Nutritional Physiological Phenomena.

Medical Subjects:

Amino Acids--metabolism.

Amino Acids--therapeutic use.

Enzymes--metabolism.

Enzyme Therapy.

Nutritional Physiological Phenomena.

Genre:

Electronic books.

Physical Description:

1 online resource (xxxiv, 544 pages) : illustrations

Place of Publication:

Wallingford, Oxfordshire ; Cambridge, MA : CABI, [2012]

System Details:

text file

Summary:

The chapters in this book are arranged within a thematic structure as indicated in the sections below. The first part pursues the theme of amino acid metabolism through the driving actions of the principal enzymes, emphasizing recent developments particularly with reference to localization, molecular genetics, biophysical characterization and regulation. Subsequent chapters will also demonstrate the changing facets of amino acid biochemistry. The competing actions of enzymes for critical substrates are also features of relevance in this section. A number of the enzymes under review here catalyse rate-limiting steps in important metabolic pathways, leading to synthesis of physiologically active intermediates and end products. There is scope for elaboration of the important pathways initiated by enzymes under review in this section. Part I has also been developed with the aim of underpinning subsequent chapters in this volume. Part II deals with important issues relating to whole-body amino acid dynamics, with a particular objective of supporting the chapters on nutrition and health that will follow. In this chapter, authors were encouraged to adopt an integrative approach to include their own expertise and that of others in their respective fields. A basic outline of metabolic pathways appears in Part I. The theme in this section centres around kinetics and regulation in broad-spectrum reviews incorporating innovative aspects of the relevant research. In other words, the concept of metabolic networking forms an underlying theme in this series of chapters. The chapters in part III cover a number of topical research investigations employing existing technologies to develop novel concepts or to underpin contemporary practices. At least four of the chapters in part IV focus on different amino acids associated with neurological issues and cognitive performance measures. The approach here is designed to reflect developments in epidemiology, monitoring, and clinical interventions in the various conditions under consideration in this section. The final section contains a plenary review designed to summarize the main findings in the foregoing chapters within an integrated account. The main theme centres around the concept of the emergence of a new momentum driving forward a progressive agenda in further elucidating the biochemical and health implications of amino acids.

Contents:

Glutamate dehydrogenase / T.J. Smith and C.A. Stanley

Aminotransferases / M.E. Conway

Arginase / R.W. Caldwell, S. Chandra and R.B. Caldwell

Bypassing the endothelial l-arganine-nitric oxide pathway: effects of dietary nitrite and nitrate on cardiovascular function / P. Luedike, M. Kelm and T. Rassaf

Histidine decarboxylase / E. Dere, O. Ambrée and A. Zlomuzica

Glutamate decarboxylase / H. Ueno ... [and others]

Glutaminase / J.M. Matés ... [and others]

D-serine and serine racemase in the retina / S.B. Smith, Y. Ha and V. Ganapathy

Tryptophan hydroxylase / I. Winge, J. McKinney and J. Haavick

Methionine metabolism / J.M. Mato, M.L. Martínez-Chantar and S.C. Lu

Amino acid transport across each side of the blood-brain barrier / R.A. Hawkins ... [and others]

Inter-organ fluxes of amino acids / M.C.G. van de Poll and C.H.C. Dejong

Cellular adaption to amino acid availability: mechanisms involved in the regulation of gene expression / J. Averous ... [and others]

Endogenous amino acids at the terminal ileum of the adult human / P.J. Moughan

Metabolic availability of amino acids in food proteins: new methodology / C.L. Levesque, R. Elango and R.O. Ball

Amino acid requirements: quantitative estimates / R.R. Pillai and A.V. Kurpad

Amino acid supplements and muscular performance / T.A. Churchward-Venne, D.W.D. West and S.M. Phillips

Amino acids in clinical and nutritional support: glutamine in duchenne muscular dystrophy / E. Mok and R. Hankard

Adverse effects / J.P.F. D'Mello

The umami taste of glutamate / X. Li

Homocysteine status: factors affecting and health risks / L.M. Steffen and B. Steffen

Modified amino acid-based molecules: accumulation and health implications / S. Bengmark

Phenylketonuria: newborn identification through to adulthood / R. Koch and K. Moseley

Principles of rapid tryptophan depletion and its use in research on neuropsychiatric disorders / F.D. Zepf

Excitatory amino acids in neurological and neurodegenerative disorders / G. Flores ... [and others]

Efficacy of L-DOPA therapy in Parkinson's Disease / G. Sahin and D. Kirik

Amino acid profiles for diagnostic applications / T. Kimura ... [and others]

Emergence of a new momentum / J.P.F. D'Mello.

Notes:

Includes bibliographical references and index.

Description based on print version record.

Other Format:

Print version: Amino acids in human nutrition and health.

ISBN:

1-283-42582-3

OCLC:

763335111

Access Restriction:

Restricted for use by site license.