Antimicrobial drug discovery : emerging strategies / editors, George Tegos and Eleftherios Mylonakis.

Format:

Book

Contributor:

Tegos, George.

Mylonakis, Eleftherios.

C.A.B. International.

Series:

Advances in molecular and cellular microbiology ; 22.

Advances in molecular and cellular microbiology ; 22

Language:

English

Subjects (All):

Anti-infective agents--Development.

Anti-infective agents.

Drug development.

Drug resistance.

Anti-Infective Agents--pharmacology.

Drug Design.

Disease Models, Animal.

High-Throughput Screening Assays--methods.

Photosensitizing Agents--pharmacology.

Medical Subjects:

Anti-Infective Agents--pharmacology.

Drug Design.

Disease Models, Animal.

High-Throughput Screening Assays--methods.

Photosensitizing Agents--pharmacology.

Genre:

Electronic books.

Physical Description:

1 online resource (x, 356 pages) : illustrations.

Place of Publication:

Wallingford, Oxfordshire : CABI, [2012]

System Details:

text file

Summary:

This book, inclusive of 22 chapters, describes novel approaches currently used for antimicrobial drug discovery, focusing on agents for use against bacterial and fungal pathogens. Specific chapters discuss: (1) concepts relevant to drug resistance; (2) microbial mechanisms related to efflux pumps and studies on their potential inhibitors; (3) impact of multidrug tolerance of biofilms and persister cells; (4) bacterial quorum-sensing inhibition; (5) inhibition of the bacterial filamentous temperature-sensitive mutant Z (FtsZ); (6) antibacterial properties of lysostaphin; (7) strategies to identify modified ribosomally synthesized antimicrobials; (8) quantitative structure-activity relationship studies of novel antimicrobial peptides; (9) bacterial acetyl-CoA carboxylase and lipopolysacharide as drug targets for antibiotic development; (10) pathosystematic systems biology for the rational design of novel antifungal compounds; (11) specific animal models for novel antimicrobial discovery; and (12) new antimicrobial technology platforms such as antimicrobial photodynamic therapy and carbon nanotubes.

Contents:

Emerging discovery strategies : an evolving necessity / Anthony R. Ball and George P. Tegos

The antibiotic crisis / Arnold L. Demain and Jaroslav Spizek

Structure, genetic regulation, physiology and function of the AcrAB-TolC efflux pump of escerichia coli and salmonella / Leonard Amaral ... [and others]

Small molecule efflux pump inhibitors from natural products as a potential source of antimicrobial agents / Sanjay M. Jachak ... [and others]

Fungal efflux-mediated resistance : from targets to inhibitors / Brian C. Monk ... [and others]

Vacuolar ATPase (V-ATPase) : a model proton pump for antifungal drug discovery

Karlett J Parra

Drug tolerance, persister cells and drug discovery / Kim Lewis

Inhibition of quorum sensing as a novel antimicrobial strategy

Gilles Brackman, Hans J. Nelis and Tom Coenye

Filamentous temperature-sensitive mutant Z (FtsZ) protein as an antibacterial target / Jaroslaw M. Boberek ... [and others]

Lysostaphin : a silver bullet for staph / John F. Kokai-Kun

Strategies to identify modified ribosomally synthesized antimicrobials

Alan J. Marsh ... [and others]

QSAR based discovery of antimicrobial peptides active against multidrug resistant bacteria / Christopher D. Fjell ... [and others]

Acetyl-CoA carboxylase as a target for antibacterial development / Grover L. Waldrop

Underexploited targets in LPS biogenenesis for the design of antibacterials / Laura Cipolla ... [and others]

Predicting and dissecting biomolecular interactions by information-driven docking / Panagiotis Kastritsis and Alexandre M.J.J Bonvin

Anti-fungals and anti-fungal drug discovery / Richard Calderone ... [and others]

Pathosystematic studies and the rational design of antifungal interventions / Elaine M Bignell and Darius Armstrong-James

In vivo high-throughput antimicrobial discovery screens utilizing caenorhabditis elegans as an alternative host / Jeffrey J. Coleman and Eleftherios Mylonakis

Drosophila melanogaster as a versatile model for discovery of drugs effective against human microbe-induced infection and pathology / Yiorgos Apidianakis and Dimitrios P. Kontoyiannis

Antimicrobial photosensitizers

harnessing the power of light to treat infections / Sulbha K Sharma, Tianhong Dai and Michael R Hamblin

Nanoparticle platforms for antimicrobial therapy / David Trofa, Joshua D. Nosanchuk

Antimicrobial activity of carbon nanotubes / Shaobin Liu, Yuan Chen.

Notes:

Description based on print version record.

Includes bibliographical references and index.

Other Format:

Print version: Antimicrobial drug discovery.

ISBN:

1-84593-943-3

OCLC:

811064904

Access Restriction:

Restricted for use by site license.