Oogenesis / Giovanni Coticchio, David F. Albertini, Lucia De Santis, editors.

Format:

Book

Contributor:

Coticchio, Giovanni.

Albertini, David F.

De Santis, Lucia.

Language:

English

Subjects (All):

Ovum.

Oogenesis.

Medical Subjects:

Ovum.

Oogenesis.

Genre:

Electronic books.

Physical Description:

1 online resource (xii, 364 pages) : illustrations (some color

Place of Publication:

London ; New York : Springer, [2013]

System Details:

Mode of access: World Wide Web.

text file

Summary:

The oocyte is the largest and most mysterious cell in the body of mammalian organisms. Through its growth and maturation, it reaches extreme levels of specialization, while maintaining at the same time a condition of totipotency. Its unique ability, in co-operation with the spermatozoon, to give rise to a fully developed organism formed from hundreds of different tissues and myriads of individual cells has inspired intellectuals of all ages.Oogenesis finds impetus and purpose in casting scientific perspective towards this unique cell for the benefit of scientists and assisted reproductive technology (ART) specialists. The authors of the chapters are distinguished authorities in their respective areas of competence. From the opening of the book the reader is lead on a fantastic voyage from the formation of the primordial oocyte to the development of the early embryo, passing through crucial processes of oogenesis, such as co-ordination of oocyte and follicle growth, gene expression and organelle reorganization during growth and maturation, epigenetic mechanisms, regulation of meiosis, totipotency, cell polarity, oogenesis in vitro and maternal regulation of early development.

Contents:

Part I: Imaging

Imaging Strategies for Studying Mammalian Oogenesis

Part II: Folliculogenesis and Oogenesis

Origin, Migration, and Proliferation of Human Primordial Germ Cells

Damage Control in the Female Germline: Protecting Primordial Follicles

Regulation of Quiescence and Activation of Oocyte Growth in Primordial Follicles

The Structural Basis for Coordinating Oogenesis and Folliculogenesis

How the Oocyte Influences Follicular Cell Function and Why

Changes of Large-Scale Chromatin Configuration During Mammalian Oocyte Differentiation

The Quest for Oogenesis (Folliculogenesis) In Vitro

Part III: The (Epi)Genetic Making of the Oocyte

Regulation of Oogenesis by Oocyte-Specific Gene Networks

An Epigenomic Biography of the Mammalian Oocyte

Epigenetic Regulation of Oocyte Function and Developmental Potential

Part IV: Oocyte Meiosis and Cytoplasmic Dynamics

Signaling for Meiotic Resumption in Granulosa Cells, Cumulus Cells, and Oocyte

Start and Stop Signals of Oocyte Meiotic Maturation

Cytoskeletal Correlates of Oocyte Meiotic Divisions

Organelle Rearrangement in the Maturing Oocyte

Origins of Oocyte Aneuploidy

Part V: Oocyte Developmental Potential

Cumulus Cell Gene Expression as a Marker of Oocyte Quality

Oocyte Polarity and Its Developmental Significance

The Role of the Plasma Membrane and Pericortical Cytoplasm in Early Mammalian Development

The Choreography of Fertilization

Determinants of Oocyte Quality: Impact on In Vitro Fertilization Failures

Maternal Diet, Oocyte Nutrition and Metabolism, and Offspring Health.

Notes:

Includes bibliographical references and index.

ISBN:

9780857298263

0857298267

OCLC:

820359342

Access Restriction:

Restricted for use by site license.