Drug resistance in leishmania parasites : consequences, molecular mechanisms and possible treatments / Alicia Ponte-Sucre, Emilia Díaz, Maritza Padrón-Nieves, editors.

Format:

Book

Contributor:

Ponte-Sucre, Alicia.

Diaz, Emilia.

Padrón-Nieves, Maritza.

Language:

English

Subjects (All):

Leishmaniasis.

Drug Resistance.

Leishmania--drug effects.

Drug resistance in microorganisms.

Medical parasitology.

Medical Subjects:

Leishmaniasis.

Drug Resistance.

Leishmania--drug effects.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

Vienna ; New York : Springer, [2013]

System Details:

Mode of access: World Wide Web.

text file

Summary:

One of the main problems concerning therapeutic tools for the treatment of parasitic diseases, including leishmaniasis, is that some field parasites are naturally resistant to the classical drugs; additionally, current therapies may select parasites prone to be resistant to the applied drugs. These features are (at least partially) responsible for the disappointing persistence of the disease and resultant deaths worldwide. This book provides a comprehensive view of the pathology of the disease itself, and of parasitic drug resistance, its molecular basis, consequences and possible treatments. Scientists both from academic fields and from the industry involved in biomedical research and drug design, will find in this book a valuable and fundamental guide that conveys the knowledge needed to understand and to improve the success in combating this disease worldwide.

Contents:

Part 1. DETERMINANT FEATURES IN LEISHMANIASIS

Molecular Evolution and Phylogeny of Leishmania / Gabriele Schönian, Elisa Cupolillo and Isabel Mauricio

The Role of Reservoirs: Canine Leishmaniasis / Lenea Campino and Carla Maia

Epidemiology of Leishmaniasis in the Time of Drug Resistance / Jean-Claude Dujardin and Saskia Decuypere

Introduction: Leishmaniasis - The Biology of a Parasite / A. Ponte-Sucre.

Part 2. Leishmania and the Immune System

The Role of the Immune System in Resistance to Infection / Lukasz Kedzierski and Krystal J. Evans

Vaccination as a Control Measure / Katrin Färber and Heidrun Moll

Leishmania Vaccines: Past, Present, and Future / Bhavana Sethu Lakshmi and Rentala Madhubala.

Part 3. CHALLENGES IN THE DIAGNOSIS, TREATMENT AND CONTROL OF LEISHMANIASIS IN TIMES OF DRUG RESISTANCE

Co-infection with HIV / Margriet den Boer, Luis Rivas and Jorge Alvar

Visceral Leishmaniasis / Shyam Sundar and Jaya Chakravarty

American Tegumentary Leishmaniasis / Olga Zerpa and Alicia Ponte-Sucre.

Part 4. MOLECULAR FEATURES OF DRUG-RESISTANT LEISHMANIA

Genetic Expression and Drug Resistance, the Role of Proteomics / Patricia Cuervo and Jose Batista de Jesus

The Role of ABC Transporters in Drug-Resistant Leishmania / Adriano C. Coelho and Paulo C. Cotrim

Functional Analysis of Leishmania Membrane (Non-ABC) Transporters Involved in Drug Resistance / Scott M. Landfear

Intracellular Mechanisms of Resistance / Mitali Chatterjee.

Part 5. PHARMACOLOGY AND CHEMOTHERAPY OF LEISHMANIASIS

Classical Versus Novel Treatment Regimens / Louis Maes, Raquel Andreia Inocencio da Luz, Paul Cos and Vanessa Yardley

Drug Targets, Drug Effectors, and Drug Targeting and Delivery / Philippe M. Loiseau and Gillian Barratt

Mechanisms of Miltefosine Resistance in Leishmania / Francisco Gamarro, María P. Sánchez-Cañete and Santiago Castanys

P-glycoprotein-like Transporters in Leishmania: A Search for Reversal Agents / Bruno Pradines.

Part 6. STRATEGIES TO CIRCUMVENT DRUG RESISTANCE IN LEISHMANIA

The Relevance of Susceptibility Tests, Breakpoints, and Markers / Louis Maes, Paul Cos and Simon L. Croft

The Concept of Fitness and Drug Resistance in Leishmania / Alicia Ponte-Sucre, Emilia Diaz and Maritza Padrón-Nieves.

Notes:

Includes index.

ISBN:

9783709111253

3709111250

OCLC:

809934165

Access Restriction:

Restricted for use by site license.