Innate tolerance in the CNS : translational neuroprotection by pre- and post-conditioning / Jeffrey M. Gidday, Miguel A. Perez-Pinzon, John H. Zhang, editors.

Format:

Book

Contributor:

Gidday, Jeffrey M.

Perez-Pinzon, Miguel A.

Zhang, J. H. (John H.)

Series:

Springer series in translational stroke research

Language:

English

Subjects (All):

Neuroprotective agents.

Central nervous system--Diseases--Treatment.

Central nervous system.

Central Nervous System Diseases--therapy.

Neuroprotective Agents.

Central nervous system--Diseases.

Medical Subjects:

Central Nervous System Diseases--therapy.

Neuroprotective Agents.

Genre:

Electronic books.

Physical Description:

1 online resource (ix, 699 pages) : illustrations.

Place of Publication:

New York, NY : Springer, [2013]

System Details:

Mode of access: World Wide Web.

text file

Summary:

Cerebral ischemia from cardiac arrest, stroke, and subarachnoid and intracerebral hemorrhage, together with trauma, epilepsy, and other CNS pathologies, continue to impose immense burdens of morbidity and mortality the world over. Despite many decades of research aimed at understanding the genetic and molecular basis of these pathologies, therapeutics developed on the basis of blocking 'known' injury mechanisms can actually claim few clinical successes. The field of CNS "preconditioning" was born from the preclinical finding more than 20 years ago that intentional activation of innate, cytoprotective factors could provide robust protection, or "tolerance" against cerebral ischemic injury. Herein, up-to-date summaries on all aspects of preconditioning for CNS disease, including the emerging topics of postconditioning and remote pre- and post-conditioning, are provided by the leading scientists in the field. The translational potential of both preclinical and clinical advances is underscored throughout, with the hope of accelerating the bench-to-bedside success of endogenous cytoprotection as a therapeutic strategy. Jeffrey M. Gidday PhD, Associate Professor of Neurosurgery at Washington University School of Medicine, has been working in the field of CNS preconditioning for 18 years, and has numerous publications on preconditioning-induced protection in the setting of several different cerebral and retinal pathologies. Miguel A. Perez-Pinzon PhD is Professor of Neurology/Neuroscience, Vice-Chair for Basic Science of Neurology at the University of Miami Miller School of Medicine. He began studies of ischemic preconditioning in 1995 and for many years prior to that worked in the field of anoxia tolerance, publishing close to 50 peer-reviewed articles and many book chapters on these topics. John H. Zhang MD PhD is Professor of Neurosurgery, Anesthesiology, and Physiology, and Vice-Chair of the Basic Science Department at the Loma Linda University School of Medicine. His research interests include stroke and medical gases, and he has published papers related to pre-, post- and remote-conditioning in subarachnoid hemorrhage, focal cerebral ischemia, and neonatal brain injury.

Contents:

Part I: Comparative Physiology and Historical Background

Tolerance, Historical Review

Anoxia Resistance in Lower and Higher Vertebrates

Hibernation: A Natural Model of Tolerance to Cerebral Ischemia/Reperfusion

Preconditioning in the Heart

Part II: Conditioning Methods

Neuroprotection and Physical Preconditioning: Exercise, Hypothermia, and Hyperthermia

A New Future in Brain Preconditioning Based on Nutraceuticals: A Focus on a-Linolenic Omega-3 Fatty Acid for Stroke Protection

Medical Gases for Conditioning: Volatile Anesthetics, Hyperbaric Oxygen, and Hydrogen Sulfide

Hypoxic Preconditioning in the CNS

Pharmacologic Preconditioning

Surgical Methods to Induce Brain Preconditioning

Part III: Conditioning Models for Cerebral Ischemia

Tolerance Against Global Cerebral Ischemia: Experimental Strategies, Mechanisms, and Clinical Applications

Preconditioning and Neuroprotection in the Immature Brain

Conditioning Studies in Focal Cerebral Ischemia: Model Selection, Physiological Monitoring, and Other Methodological Issues

Preconditioning for SAH

Preconditioning and Intracerebral Hemorrhage

The Protective Effects of Ischemic Postconditioning in Experimental Stroke

Part IV: Mechanisms of Preconditioning

Synaptic Signaling in Ischemic Tolerance

The Genomics of Preconditioning and Ischemic Tolerance

How Do Subcellular Organelles Participate in Preconditioning-Conferred Neuroprotection?

Ischemic Preconditioning-Mediated Signaling Pathways Leading to Tolerance Against Cerebral Ischemia

Preconditioning the Neurovascular Unit: Tolerance in the Brain's Nonneuronal Cells

Part V: Other Neurological Disorders

Preconditioning for Surgical Brain Injury

Intrinsic Neuroprotection in Traumatic Brain Injury

Preconditioning for Epilepsy

Ischemic Pre- and Post-conditioning in the Retina

Part VI: Clinical Applications

Clinical Cerebral Preconditioning and Postconditioning

Preconditioning Strategy: Coronary Bypass, Subarachnoid Hemorrhage, Temporary Proximal Vessel Occlusion in Carotid Revascularization, and Intracranial Aneurysm Surgery

HBO Preconditioning for TBI and Stroke Patients

Electroacupuncture Preconditioning for Stroke Patients

Clinical Trials of Ischemic Conditioning.

Notes:

Includes bibliographical references and indexes.

ISBN:

9781441996954

1441996958

OCLC:

811772992

Access Restriction:

Restricted for use by site license.