Renal disease in cancer patients / edited by Kevin W. Finkel, Scott C. Howard.

Format:

Book

Contributor:

Finkel, Kevin W.

Howard, Scott C.

ScienceDirect (Online service)

Language:

English

Subjects (All):

Kidneys--Diseases.

Kidneys.

Cancer--Complications.

Cancer.

Genre:

Electronic books.

Physical Description:

1 online resource

Place of Publication:

Amsterdam ; Boston : Academic Press, 2013.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chapters. Summarizes all renal diseases unique to cancer patients in a single reference. Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training.

Contents:

1 Introduction / Scott C. Howard Howard, Scott C., Kevin W. Finkel Finkel, Kevin W.

References 2

2 Acute Kidney Injury in Cancer Patients / Joseph R. Angelo Angelo, Joseph R., Joshua A. Samuels Samuels, Joshua A.

Introduction 3

Defining Acute Kidney Injury 4

Classification of Acute Kidney Injury 4

Conclusion 16

References 17

3 Biomarkers in Oncology and Nephrology / Putab Cen Cen, Putab, Carl Walther Walther, Carl, Kevin W. Finkel Finkel, Kevin W., Robert J. Amato Amato, Robert J.

Introduction 21

Biomarkers in Oncology 22

Biomarkers in Nephrology 31

Summary 34

References 35

4 Tumor Lysis Syndrome / Scott C. Howard Howard, Scott C., Ching-Hon Pui Pui, Ching-Hon, Raul C. Ribeiro Ribeiro, Raul C.

Introduction 39

Definition of Tumor Lysis Syndrome 40

Pathophysiology 41

Tumor Lysis Syndrome: One Syndrome or Several? 45

Epidemiology and Risk Factors 46

Risk Assessment 48

Grading of Tumor Lysis Syndrome. Severity 49

Management 49

Sequelae of Tumor Lysis Syndrome 60

Prevention of Tumor Lysis Syndrome by Altering Initial Cancer Therapy 60

Summary 60

References 61

5 Multiple Myeloma and Kidney Disease / Amit Lahoti Lahoti, Amit

Introduction 65

Cast Nephropathy 66

AL Amyloidosis 67

LCDD 69

Bisphosphonates 70

Renal Transplant 70

References 70

6 Kidney Disease in Patients Undergoing Hematopoietic Cell Transplantation / Benjamin L. Laskin Laskin, Benjamin L., Sangeeta R. Hingorani Hingorani, Sangeeta R.

Introduction 73

Current Practice of HCT 74

Evaluation of Kidney Disease During HCT 75

Acute Kidney Injury 80

Chronic Kidney Disease 84

Specific Kidney Diseases After HCT 89

Conclusion 94

References 95

7 Radiation-associated Kidney Injury / Amber S. Podoll Podoll, Amber S., Mark J. Amsbaugh Amsbaugh, Mark J.

Introduction 105

Pathogenesis 105

Epidemiology 107

Modern Radiation and the Kidneys 108

Clinical Presentation 109

Diagnosis 110

Treatment 110

Prognosis 110

Summary 111

References 111

8 Molecular-targeted Therapy for Renal Cell Carcinoma / Robert J. Amato Amato, Robert J., Mika Stepankiw Stepankiw, Mika, Nwabugwu S. Ochuwa Ochuwa, Nwabugwu S.

Introduction 115

Mechanisms of Action 119

Molecular-targeted Drugs 121

Summary 124

References 125

9 Renal Tumors in Children / Kelly L. Vallance Vallance, Kelly L., Jeffrey S. Dome Dome, Jeffrey S.

Renal Tumors in Children/Adolescents 129

Wilms Tumor 129

Non-Wilms Renal Tumors 148

Surveillance after Completion of Therapy 150

References 153

10 Renal Effects of Leukemia and Lymphoma / Kevin W. Finkel Finkel, Kevin W.

Introduction 161

Lymphoma 161

Cytotoxic Nephropathy/Hemophagocytic Syndrome 162

Leukemia 163

References 164

11 Fluid and Electrolyte Abnormalities in Patients with Cancer / Ala Abudayyeh Abudayyeh, Ala, Maen Abdelrahim Abdelrahim, Maen, Abdulla Salahudeen Salahudeen, Abdulla

Introduction 167

Sodium and Water 167

Hypoalbuminemia, Intravascular Volume Contraction and Hyponatremia 170

Clinical Outcomes in Cancer Patients with Hyponatremia 170

Potassium 171

Magnesium 173

Uric Acid 175

Phosphate 176

Calcium 177

Renal 179

Causes of Hypocalcemia 179

References 181

12 Infections of the Kidney in Cancer Patients / Brett Stephens Stephens, Brett

Introduction 183

Epidemiology 183

Bacterial Infections 184

Fungal Infections 186

Parasite Infections 187

Viral Infections 187

Summary 191

References 191

13 Drug Nephropathies / Ilya G. Glezerman Glezerman, Ilya G.

Introduction 195

Agents with Predominantly Tubular Toxicity 195

Agents With Predominantly Glomerular Toxicity 200

Agents Associated with Electrolyte Abnormalities 203

Conclusions 204

References 205

14 Paraneoplastic Glomerulopathy / Sheron Latcha Latcha, Sheron, Surya V. Seshan Seshan, Surya V.

General Features 209

Glomerular Lesions in Solid Tumors 213

The Hematologic Malignancies 230

Screening Recommendations for Paraneoplastic Glomerulonephritis 243

Management of Paraneoplastic Glomerulonephritis 243

References 244

15 Pharmacokinetics of Anti-cancer Chemotherapy in Renal Insufficiency and Dialysis / William H. Fissell, IV Fissell, William H. IV, Marc Earl Earl, Marc

Introduction 251

Drug Properties that Influence Renal and Extracorporeal Elimination 252

Hemodialysis and Antineoplastic Agents 253

Cell Kinetic Theory of Chemotherapy 253

Classes of Antineoplastic Agents 254

Summary 264

References 264

16 Cancer in Renal Transplant Patients / Aleksandra M. De Golovine Golovine, Aleksandra M. De, Horacio E. Adrogue Adrogue, Horacio E.

Introduction 271

Incidence 272

Causes 274

Diagnosis and Treatment 279

Prevention 281

Conclusion 284

References 285.

Notes:

Description based on print version record.

Includes index.

Other Format:

Print version:

ISBN:

1299841147

9781299841147

9780124159488

0124159486

OCLC:

857711848

Access Restriction:

Restricted for use by site license.