Proteomic applications in cancer detection and discovery / Timothy D. Veenstra, Laboratory of Proteomics and Analytical Technologies, Advanced Technologies Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research.

Format:

Book

Author/Creator:

Veenstra, Timothy Daniel, 1966-

Contributor:

Wiley InterScience (Online service)

Rebecca Pepper Sinkler Fund.

Language:

English

Subjects (All):

Cancer--Genetic aspects.

Cancer.

Proteomics.

Biochemical markers.

Physical Description:

1 online resource (ix, 308 pages) : illustrations

Place of Publication:

Hoboken, New Jersey : John Wiley & Sons, Inc., [2013]

System Details:

text file

Summary:

Proteomic data is increasingly important to understanding the origin and progression of cancer; however, most oncologic researchers who depend on proteomics for their studies do not collect the data themselves. As a result, there is a knowledge gap between scientists, who devise proteomic techniques and collect the data, and the oncologic researchers, who are expected to interpret and apply proteomic data. Bridging the gap between proteomics and oncology research, this book explains how proteomic technology can be used to address some of the most important questions in cancer research. Proteomic Applications in Cancer Detection and Discovery enables readers to understand how proteomic data is acquired and analyzed and how it is interpreted. Author Timothy Veenstra has filled the book with examples-many based on his own firsthand research experience-that clearly demonstrate the application of proteomic technology in oncology research, including the discovery of novel biomarkers for different types of cancers. The book begins with a brief introduction to systems biology, explaining why cancer is a systems biology disease. Next, it covers such topics as: Mass spectrometry in cancer research, Application of proteomics to global phosphorylation analysis, Search for biomarkers in biofluids, Rise and fall of proteomic patterns for cancer diagnostics, Emergence of protein arrays, Role of proteomics in personalized medicine, The final chapter is dedicated to the future prospects of proteomics in cancer research. By guiding readers through the latest proteomic technologies and their applications in cancer research, Proteomic Applications in Cancer Detection and Discovery enhances the ability of researchers in proteomics and researchers in oncology to collaborate in order to better understand cancer and develop strategies to prevent and treat it. Book jacket.

Contents:

1 Systems Biology 1

2 Mass Spectrometry in Cancer Research 27

3 Quantitative Proteomics 59

4 Proteomic Analysis of Posttranslational Modifications 87

5 Characterization of Protein Complexes 117

6 Global Phosphorylation Analysis 145

7 The Search for Biomarkers in Biofluids 171

8 Proteomic Patterns: A New Paradigm in Diagnostics and Therapeutics? 195

9 The Emergence of Protein Arrays 215

10 The Role of Proteomics in Personalized Medicine 241

11 The Critical Role of Bioinformatics 263

12 Future Prospects of Proteomics in Cancer Research 281.

Notes:

Includes bibliographical references and index.

Electronic reproduction. Hoboken, N.J. Available via World Wide Web.

Description based on online resource; title from digital title page (viewed on August 6, 2013).

Local Notes:

Acquired for the Penn Libraries with assistance from the Rebecca Pepper Sinkler Fund.

Other Format:

Print version: Veenstra, Timothy Daniel, 1966- Proteomic applications in cancer detection and discovery

ISBN:

9781118634561

111863456X

9781118634417

1118634411

9781118634592

1118634594

Publisher Number:

99955035149

Access Restriction:

Restricted for use by site license.