Primer on the metabolic bone diseases and disorders of mineral metabolism / editor-in-chief, Clifford J. Rosen ; senior associate editors, Roger Bouillon, Juliet E. Compston, Vicki Rosen ; associate editors, Douglas C. Bauer ... [and others].

Format:

Book

Contributor:

Rosen, Clifford J.

Bouillon, R.

Compston, Juliet E.

Rosen, Vicki

EBSCOhost.

Alumni and Friends Memorial Book Fund.

Language:

English

Subjects (All):

Bones--Metabolism--Disorders.

Bones.

Mineral metabolism--Disorders.

Mineral metabolism.

Bones--Diseases.

Bone Diseases, Metabolic.

Bone and Bones--metabolism.

Minerals--metabolism.

Medical Subjects:

Bone Diseases, Metabolic.

Bone and Bones--metabolism.

Minerals--metabolism.

Physical Description:

1 online resource (xxvi, 1078 pages)

polychrome

Edition:

Eighth edition.

Place of Publication:

Ames, Iowa : Wiley-Blackwell, 2013.

System Details:

text file

Contents:

Cover; Title page; Copyright page; Contents; Contributors; Primer Corporate Sponsors; Preface to the Eighth Edition of the Primer; About ASBMR; President's Preface; About the Companion Website; Section I: Molecular Cellular and Genetic Determinants of Bone Structure and Formation; 1: Skeletal Morphogenesis and Embryonic Development; Early Skeletal Patterning; Craniofacial patterning; Axial patterning; Limb patterning; Embryonic Cartilage and Bone Formation; Chondrocyte Proliferation and Differentiation in The Developing Cartilage; Regulation of Chondrocyte Survival; Conclusions; References.

2: Signal Transduction Cascades Controlling Osteoblast DifferentiationIntroduction; Runx2 and Osterix Transcription Factors; BMP Signaling; TGF-€ Signaling; WNT Signaling; Hedgehog Signaling; PTH Signaling; IGF-1 Signaling; FGF Signaling; Notch Signaling; Concluding Remarks; Acknowledgments; References; 3: Osteoclast Biology and Bone Resorption; Cell Biology of The Osteoclast; Integrin Signaling; Small GTPases; Factors Regulating Osteoclast Formation And/Or Function; Proteins; Small molecules; Cell-Cell Interactions in Bone Marrow; Intracellular Signaling Pathways; Human Genetics; References.

4: OsteocytesIntroduction; Osteocyte Ontogeny; Osteocytes as Orchestrators of Bone (Re)Modeling; Osteocyte Cell Death and Apoptosis; Osteocyte Modification of Their Microenvironment; Mechanosensation and Transduction; Role of Gap Junctions and Hemichannels in Osteocyte Communication; The Potential Role of Osteocytes in Bone Disease; Acknowledgment; References; 5: Connective Tissue Pathways That Regulate Growth Factors; Introduction; The Fibrillinopathies; Fibrillin Microfibrils; Regulation of Growth Factors by Fibrillin Microfibrils; Molecular Mechanisms Orchestrated on a Microfibril Scaffold.

Nanocomputed TomographyImaging Considerations; Voxel size and image resolution; Segmentation; Skeletal site and volume of interest; Calibration; Other considerations; Conclusions; References; 8: Animal Models: Genetic Manipulation; Introduction; Overexpression of Target Genes; Chondrocytes; Osteoblasts; Tendon and ligament; Osteoclasts; Advantages and disadvantages of overexpression approaches; Gene Targeting; Advantages and disadvantages of gene targeting; Tissue-Specific and Inducible Knockout and Overexpression; Uncondensed mesenchyme, mesenchymal condensations, and neural crest; Cartilage; Osteoblasts.

Notes:

Includes bibliographical references and index.

Electronic reproduction. Ipswich, MA Available via World Wide Web.

Description based on online resource; title from digital title page (viewed on Sept. 10, 2013).

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

Other Format:

Print version: Primer on the metabolic bone diseases and disorders of mineral metabolism.

ISBN:

9781118453902

1118453905

9781118453926

1118453921

Publisher Number:

99954997895

Access Restriction:

Restricted for use by site license.