The new paradigm of immunity to tuberculosis / Maziar Divangahi, editor.

Format:

Book

Contributor:

Divangahi, Maziar, editor.

Series:

Advances in experimental medicine and biology ; 783.

Advances in experimental medicine and biology

Language:

English

Subjects (All):

Tuberculosis--Immunological aspects.

Tuberculosis.

Tuberculosis--Vaccination.

Tuberculosis--immunology.

Adaptive Immunity--immunology.

Immunity, Innate--immunology.

Macrophages, Alveolar--immunology.

Medical Subjects:

Tuberculosis--immunology.

Adaptive Immunity--immunology.

Immunity, Innate--immunology.

Macrophages, Alveolar--immunology.

Physical Description:

vi, 292 pages : illustrations (some color), map ; 24 cm.

Place of Publication:

New York : Springer, [2013]

Summary:

This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former's role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed.The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection.Finally, it is a synthesis of the authors' recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.

Contents:

Epidemiology of tuberculosis immunology / G.J. Fox and D. Menzies

Host-pathogen specificity in tuberculosis / Tania Di Pietrantonio and Erwin Schurr

Genetic determinants of susceptibility to mycobacterial infections: IRF8, a new kid on the block / S. Salem and P. Gros

Evolution of Mycobacterium tuberculosis / Marcel A. Behr

Mycobacterium tuberculosis genes involved in regulation of host cell death / Volker Briken

Dying to live: how the death modality of the infected macrophage modulates immunity to tuberculosis / Maziar Divangahi, Samuel M. Behar, and Heinz Remold

Cytokines in the balance of protection and pathology during mycobacterial infections / Egído Torrado and Andrea M. Cooper

Antigen-specific CD8⁺ T cells and protective immunity to tuberculosis / Samuel M. Behar

Foxp3⁺ regulatory T cells in tuberculosis / Ryan P. Larson, Shahin Shafiani, and Kevin B. Urdahl

CD1a, CD1b, and CD1c in immunity against mycobacteria / Ildiko Van Rhijn, Dalam Ly, and D. Branch Moody

CD1d and natural killer T cells in immunity to Mycobacterium tuberculosis / Pooja Arora, Erin L. Foster, and Steven A. Porcelli

The role of B cells and humoral immunity to Mycobacterium tuberculosis infection / Lee Kozakiewicz ... [et al.]

Looking within the Zebrafish to understand the tuberculous granuloma / Lalita Ramakrishnan

Immunization strategies against pulmonary tuberculosis: considerations of T cell geography / Carly N. Horvath and Zhou Xing.

Notes:

Includes bibliographical references and index.

ISBN:

9781461461104

1461461103

OCLC:

813947105