Metabolism and disease / meeting organized by Terri Grodzicker, David Stewart, and Bruce Stillman.

Format:

Book

Conference/Event

Contributor:

Grodzicker, Terri.

Stewart, David J. (David Johnston)

Stillman, Bruce.

Cold Spring Harbor Laboratory.

Conference Name:

Cold Spring Harbor Symposium on Quantitative Biology (76th : 2011)

Series:

Cold Spring Harbor symposia on quantitative biology (Series) ; v. 76.

Cold Spring Harbor symposia on quantitative biology ; v. 76

Language:

English

Subjects (All):

Metabolism--Congresses.

Metabolism.

Bioenergetics--Congresses.

Bioenergetics.

Cell metabolism--Congresses.

Cell metabolism.

Energy metabolism--Regulation--Congresses.

Energy metabolism.

Diseases--Causes and theories of causation--Congresses.

Diseases.

Diseases--Causes and theories of causation.

Energy metabolism--Regulation.

Genre:

Conference papers and proceedings.

Physical Description:

xviii, 422 pages : illustrations (some color) ; 28 cm.

Place of Publication:

[Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory Press, 2011.

Summary:

"The Symposium aimed to integrate a very broad field of investigative effort, bringing together advances in our understanding of energy intake, consumption, and storage (diet, exercise, and fat), oxygen regulation and hypoxia, circadian rhythms, and life span/aging. The Symposium explored metabolism at molecular (gene expression, posttranslational modifications, protein turnover, cofactors and integrators, hormones, and signals), organellar (mitochondria), cellular, organ system (cardiovascular, bone), and organismal (timing and life span) scales. Diseases impacted by metabolic imbalance or dysregulation that were covered in detail included diabetes, obesity, metabolic syndrome, and cancer. New and emerging technologies were presented for simultaneous monitoring of hundreds of metabolites that allow for sophisticated sampling of the metabolic state of cells. Because the Symposium covered such a broad field, by necessity much excellent work could not be included, and instead, the Proceedings should be viewed as a necessarily eclectic collection of some of the most interesting and stimulating work that came to the organizers' attention during the 18 months before the meeting"--P. XV.

Contents:

Bioenergetic origins of complexity and disease / D.C. Wallace

Nuclear receptors and AMPK : resetting metabolism / W. Fan, M. Downes, A. Atkins, R. Yu, and R.M. Evans

Rethinking the regulation of cellular metabolism / C.B. Thompson

The time of metabolism : NAD+, SIRT1, and the circadian clock / M.M. Bellet, R. Orozco-Solis, S. Sahar, K. Eckel-Mahan, and P. Sassone-Corsi

The mammalian circadian timing system : synchronization of peripheral clocks / C. Saini, D.M. Suter, A. Liani, P. Gos, and U. Schibler

Circadian epigenomic remodeling and hepatic lipogenesis : lessons from HDAC3 / Z. Sun, D. Feng, L.J. Everett, A. Bugge, and M.A. Lazar

Estrogen-related receptor [alpha], the molecular clock, and transcriptional control of metabolic outputs / V. Giguère, C.R. Dufour, L.J. Eichner, G. Deblois, and N. Cermakian

Circadian clocks in fuel harvesting and energy homeostasis / K.M. Ramsey and J. Bass

Gamete formation resets the aging clock in yeast / E. Ünal and A. Amon

Sirtuins, aging, and metabolism / L. Guarente

The heat shock response : systems biology of proteotoxic stress in aging and disease / R.I. Morimoto

Skeletal muscle stem cells : effects of aging and metabolism on muscle regenerative function / Y.C. Jang, M. Sinha, M. Cerletti, C. Dall'Osso, and A.J. Wagers

The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status / K.D. Kimura, D.L. Riddle, and G. Ruvkun

Surviving starvation : essential role of the Ghrelin-growth hormone axis / J.L. Goldstein, T.-j. Zhao, R.L. Li, D.P. Sherbet, G. Liang, and M.S. Brown

Transcriptional and posttranscriptional control of cholesterol homeostasis by liver X receptors / P. Tontonoz

Roles of FGF19 in liver metabolism / S. Kir, S.A. Kliewer, and D.J. Mangelsdorf

A new approach to an old problem : synthetic biology tools for human disease and metabolism / D.R. Burrill, P.M. Boyle, and P.A. Silver

Adenosine monophosphate activated protein kinase : a central regulator of metabolism with roles in diabetes, cancer, and viral infection / D.G. Hardie

Regulated histone methyltransferase and demethylase complexes in the control of genes by nuclear receptors / A. Yokoyama, R. Fujiki, F. Ohtake, and S. Kato

Transcriptional control of cardiac fuel metabolism and mitochondrial function / T.C. Leone and D.P. Kelly

Metabolic specialization of mouse embryonic stem cells / J. Wang, P. Alexander, S.L. McKnight

On acetyl-CoA as a gauge of cellular metabolic state / L. Cai and B.P. Tu

Nutrient-dependent acetylation controls basic regulatory metabolic switches and cellular reprogramming / J.E. Dominy, Z. Gerhart-Hines, and P. Puigserver

Control of glycolysis through regulation of PFK1 : old friends and recent additions / I. Mor, E.C. Cheung, and K.H. Vousden

ENTPD5, an endoplasmic reticulum UDPase, alleviates ER stress induced by protein overloading in AKT-activated cancer cells / Z. Shen, S. Huang, M. Fang, and X. Wang

MicroRNAs in metabolism and metabolic diseases / V. Rottiers, S.H. Najafi-Shoushtari, F. Kristo, S. Gurumurthy, L. Zhong, Y. Li, D.E. Cohen, R.E. Gerszten, N. Bardeesy, R. Mostoslavsky, and A. M. Näär

Metabolomics in drug target discovery /J.D. Rabinowitz, J.G. Purdy, L. Vastag, T. Shenk, and E. Koyuncu

Transcriptional networks controlling adipocyte differentiation / R. Siersbæk and S. Mandrup

Adiponectin, adiponectin receptors, and epigenetic regulation of adipogenesis / T. Kadowaki, T. Yamauchi, H. Waki, M. Iwabu, M. Okada-Iwabu, and M. Nakamura

SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism / M.D. Hirschey, T. Shimazu, J.-Y. Huang, B. Schwer, and E. Verdin

Regulation of male fertility by bone / G. Karsenty

Regulation of glycolysis and gluconeogenesis by acetylation of PKM and PEPCK / Y. Xiong, Q-Y. Lei, S. Zhao, and K-L. Guan

NAD+ as a signaling molecule modulating metabolism / C. Cantó and J. Auwerx

Cancer cell metabolism / R.A. Cairns, I. Harris, S. McCracken, and T.W. Mak

Extracellular matrix regulation of metabolism and implications for tumorigenesis / A.R. Grassian, J.L. Coloff, and J.S. Brugge

Metabolic pathway alterations that support cell proliferation / M.G. Vander Heiden, S.Y. Lunt, T.L. Dayton, B.P. Fiske, W.J. Israelsen, K.R. Mattaini, N.I. Vokes, G. Stephanopoulos, L.C. Cantley, C.M. Metallo, and J.W. Locasale

Cancer and altered metabolism : potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases / W.G. Kaelin, Jr.

Regulation of metabolism by hypoxia-inducible factor 1 / G.L. Semenza

mRNA translation and energy metabolism in cancer : the role of the MAPK and mTORC1 pathways / I. Topisirovic and N. Sonenberg

Therapeutic targeting of Myc-reprogrammed cancer cell metabolism / C.V. Dang

Integration of apoptosis and metabolism / C.H. Yi, H. Vakifahmetoglu-Norberg, J. Yuan

Autophagy, stress, and cancer metabolism : what doesn't kill you makes you stronger / R. Mathew and E. White

Autophagy in protein and organelle turnover / N. Mizushima

Back to the future : molecular biology meets metabolism / S. McKnight.

Notes:

Includes bibliographical references and indexes.

ISBN:

9781936113569

1936113562

9781936113576

1936113570

OCLC:

808098369