Modern tools for the synthesis of complex bioactive molecules / edited by Janine Cossy, Stellios Arseniyadis.

Format:

Book

Contributor:

Arseniyadis, S. (Stellios)

Cossy, Janine.

Language:

English

Subjects (All):

Biomolecules--Synthesis.

Biomolecules.

Physical Description:

xiii, 581 pages : illustrations (some color) ; 24 cm

Place of Publication:

Hoboken, N.J. : John Wiley, [2012]

Summary:

"An overview of the new technologies that have revolutionized organic chemistry and allowed easy access to complex bioactives, this book brings modern synthetic techniques and bioactives together. The synthesis of structurally complex molecules has become a real challenge for the synthetic community. The development of innovative methodologies enabling control of the exact connectivity of the atoms within a molecule and setting correct three-dimensional arrangements, have gained a great interest. Combining representative experimental procedures for particular methods, the book is suited for advanced students, researchers, and pharmaceutical employees"-- Provided by publisher.

"This book provides an overview of the new technologies that have revolutionized organic chemistry and allowed an easy access to very important complex bioactives. It is the only book of its kind assocating modern synthetic techniques and structurally complex bioactives, and includes some representative experimental procedures for particular methods. The synthesis of structurally complex molecules has become a real challenge among the synthetic community"-- Provided by publisher.

Contents:

Chapter 1 C-H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products / Sophie Rousseaux Rousseaux, Sophie, Benoît Liégault Liégault, Benoît, Keith Fagnou Fagnou, Keith 1

Chapter 2 The Negishi Cross-Coupling in the Synthesis of Natural Products and Bioactive Molecules / Evelina Colacino Colacino, Evelina, Jean Martinez Martinez, Jean, Frédeéric Lamaty Lamaty, Frédeéric 33

Chapter 3 Metal-Catalyzed C-Heteroatom Cross-Coupling Reactions / Renata Marcia de Figueiredo Figueiredo, Renata Marcia de, Jean Marc Campagne Campagne, Jean Marc, Damien Prim Prim, Damien 77

Chapter 4 Golden Opportunities in the Synthesis of Natural Products and Biologically Active Compounds / Fabien Gagosz Gagosz, Fabien 111

Chapter 5 Metathesis-Based Synthesis of Complex Bioactives / Jean-Alexandre Richard Richard, Jean-Alexandre, Sin Yee Ng Ng, Sin Yee, David Y.-K. Chen Chen, David Y.-K. 155

Chapter 6 Enantioselective Organocatalysis: A Powerful Tool for the Synthesis of Bioactive Molecules / Mitsuru Shoji Shoji, Mitsuru, Yujiro Hayashi Hayashi, Yujiro 189

Chapter 7 Asymmetric Phase-Transfer Catalysis / Seiji Shirakawa Shirakawa, Seiji, Shin A. Moteki Moteki, Shin A., Keiji Maruoka Maruoka, Keiji 213

Chapter 8 Rearrangements in Natural Product Synthesis / José Marco-Contelles Marco-Contelles, José, Elena Soriano Soriano, Elena 243

Chapter 9 Domino Reactions in the Enantioselective Synthesis of Bioactive Natural Products / Lutz F. Tietze Tietze, Lutz F., Scott G. Stewart Stewart, Scott G., Alexander Düfert Düfert, Alexander 271

Chapter 10 Fluorous Linker-Facilitated Synthesis of Biologically Interesting Molecules / Wei Zhang Zhang, Wei 335

Chapter 11 The Evolution of Immobilized Reagents and their Application in Flow Chemistry for the Synthesis of Natural Products and Pharmaceutical Compounds / Rebecca M. Myers Myers, Rebecca M., Kimberley A. Roper Roper, Kimberley A., Ian R. Baxendale Baxendale, Ian R., Steven V. Ley Ley, Steven V. 359

Chapter 12 Synthetic Approaches to Bioactive Carbohydrates / Xavier Guinchard Guinchard, Xavier, Sébastien Picard Picard, Sébastien, David Crich Crich, David 395

Chapter 13 Ammonium Ylides as Building Blocks for Alkaloid Synthesis / Scott Bur Bur, Scott, Albert Padwa Padwa, Albert 433

Chapter 14 Precursor-Directed Biosynthesis of Polyketide and Nonribosomal Peptide Natural Products / Colin J. B. Harvey Harvey, Colin J. B., Chaitan Khosla Khosla, Chaitan 485

Chapter 15 Target-Oriented and Diversity-Oriented Organic Synthesis / Raphaël Rodriguez Rodriguez, Raphaël 513

Chapter 16 DNA as a Tool for Molecular Discovery / Michael Smietana Smietana, Michael, Jean-Jacques Vasseur Vasseur, Jean-Jacques, Janine Cossy Cossy, Janine, Stellios Arseniyadis Arseniyadis, Stellios 539.

Notes:

Includes bibliographical references and index.

ISBN:

9780470616185

0470616180

OCLC:

707263780