The neurobiology of the prefrontal cortex : anatomy, evolution, and the origin of insight.

Format:

Book

Author/Creator:

Passingham, R. E., 1943-

Contributor:

ebrary, Inc.

Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.

Series:

Oxford psychology series ; v. 50.

Oxford psychology series ; v. [50]

Language:

English

Subjects (All):

Prefrontal cortex--Physiology.

Prefrontal cortex.

Physical Description:

1 online resource (xxii, 399 pages).

Place of Publication:

Oxford : Oxford University Press, 2012.

System Details:

text file

Contents:

1 Introduction 1

Introduction 1

Aims 2

Definitions and terminology 3

Fingerprints 12

Lesions and activation 18

Lesions and activity 20

Activity and activation 22

Conclusions 24

2 Evolution of the primate prefrontal cortex 26

Introduction 26

Strepsirrhine PF cortex 31

Ventral premotor cortex 41

Early primates 43

Anthropoid PF cortex 49

Ancestral and advanced anthropoids 51

Conclusions 62

3 Medial prefrontal cortex: choosing actions based on outcomes 65

Introduction 65

Areas 66

Connections 67

Decisions, choices, and goals 71

Accumulator networks 71

Agranular cortex in rodents 75

Agranular cortex in primates 83

Granular cortex 89

Conclusions 94

4 Orbital prefrontal cortex: choosing objects based on outcomes 97

Introduction 97

Areas 98

Connections 99

Agranular cortex in rodents 102

Agranular areas in primates 106

Granular cortex 108

Conclusions 128

5 Caudal prefrontal cortex: searching for goals 132

Introduction 132

Areas 133

Connections 134

The FEF as a prefrontal area 136

Oculomotor delayed response task 140

Attention based on learning 150

Conclusions 154

6 Dorsal prefrontal cortex: generating goals based on recent events 157

Introduction 157

Areas 158

Connections 159

Delayed response task 161

The role of interference 166

Temporal order 169

Rules 171

Prospective coding 173

Generation of goals 180

Planning a sequence 182

Conjunctions and the current context 186

Conclusions 191

7 Ventral prefrontal cortex: generating goals based on visual and auditory contexts 195

Introduction 195

Areas 196

Connections 196

Visual and auditory conditional tasks 198

Visuospatial and visuomotor associations 200

Matching-to-sample tasks 201

Categorization 204

Abstract rules 209

Changing rules 211

Abstract strategies 214

Conclusions 216

8 Prefrontal cortex as a whole: generating goals from current contexts and events 220

Introduction 220

Connections 221

Hierarchies 225

Generating goals based on contexts 232

Generating goals based on events 234

Generating goals based on attentive control 248

Fundamental function of the PF cortex 254

Conclusions 263

9 Human prefrontal cortex: generating goals from instructions and imagination 265

Introduction 265

The frontal lobes in hominid evolution 266

Microstructure and internal connections 271

External connections 272

Broca's area 273

Polar PF cortex 274

Dorsal paracingulate cortex 275

Activations in the human brain 276

Sensory processing 276

Generation of goals 280

Task instructions 283

Monitoring intentions 287

Monitoring outcomes 290

Associative learning 291

Episodic memory 295

Reasoning 298

Moral and social rules 301

Conclusions 303

10 Conclusions 309

Introduction 309

Theories based on evidence from monkeys 312

Theories based on evidence from human subjects 325

Our proposal assessed against the same criteria 335

Falsifiability of our proposal 336.

Notes:

Description based on print version record.

Electronic reproduction. Palo Alto, Calif. Available via World Wide Web.

Local Notes:

Acquired for the Penn Libraries with assistance from the Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.

Other Format:

Print version: The neurobiology of the prefrontal cortex.

ISBN:

0191633097

9780191633096

Publisher Number:

99950092432

Access Restriction:

Restricted for use by site license.