Tumour necrosis factor and related cytotoxins / [editors: Gregory Bock (Organizer) and Joan Marsh].

Format:

Book

Conference/Event

Contributor:

Bock, Gregory.

Marsh, Joan.

Ciba Foundation.

Conference Name:

Symposium on Tumour Necrosis Factor and Related Cytokines (1987 : Ciba Foundation, London)

Series:

Coba Foundation symposium ; new ser., 121.

Ciba Foundation symposium ; 131

Language:

English

Subjects (All):

Antigens, Neoplasm--immunology.

Tumor Necrosis Factor-alpha.

Endotoxins.

Tumor necrosis factor--Congresses.

Tumor necrosis factor.

Cytokines--Congresses.

Cytokines.

Medical Subjects:

Antigens, Neoplasm--immunology.

Tumor Necrosis Factor-alpha.

Endotoxins.

Genre:

Conference papers and proceedings.

Physical Description:

ix, 241 pages : illustrations ; 24 cm.

Place of Publication:

Chichester ; New York : Wiley, 1987.

Summary:

The number of factors implicated in the regulation of cell proliferation and differentiation is already considerable and more are continually being identified. This book concentrates on tumor necrosis factor (cachectin) and lymphotoxin, but includes observations of their interactions with other cytokines, especially the interferons and interleukins. TNF can be either cytostatic or cytotoxic to cultured cell lines, and a variety of mechanisms are proposed, ranging from DNA fragmentation to activation of phospholiopases. TNF is also reported to stimulate the growth of normal fibroblasts "in vivo." The "in vivo" actions of TNF described here include haemorrhagic necrosis of tumors, cachexia, effects on the vasculature, and antiparasitic and antiviral activities. Also presented is some interesting data from the first stages of clinical trials of TNF as an anticancer agent.

Notes:

"Symposium on Tumour Necrosis Factor and Related Cytokines, held at the Ciba Foundation, London, 20-22 January 1987"--P. v.

"A Wiley-Interscience publication."

Includes bibliographical references and indexes.

ISBN:

047191097X :

OCLC:

16128889