Biodefense : research methodology and animal models / edited by James R. Swearengen.

Format:

Book

Contributor:

Swearengen, James R.

Language:

English

Subjects (All):

Bioterrorism--Prevention--Research.

Bioterrorism.

Infection--Animal models.

Infection.

Communicable diseases--Research.

Communicable diseases.

Biological weapons.

Alternative toxicity testing.

Toxins--Research.

Toxins.

Models, Animal.

Research Design.

Toxins, Biological--toxicity.

Research.

Bioterrorism--Prevention.

Medical Subjects:

Bioterrorism.

Models, Animal.

Research Design.

Toxins, Biological--toxicity.

Physical Description:

xiv, 401 pages : illustrations (some color) ; 25 cm

Edition:

Second edition.

Place of Publication:

Boca Raton, FL : CRC Press, [2012]

Summary:

Significant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA's Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, Biodefense Research Methodology and Animal Models, Second Edition spans the spectrum of coverage from basic research to advanced development of medical countermeasures.

Topics discussed in this volume include:

A history of biological agents as weapons, from the use of corpses to contaminate water supplies to modern day anthrax attacks

Concepts and strategies involved in biowarfare and bioterrorism

The development, validation, and importance of animal models in biodefense research

Infectious disease aerobiology

Studies involving anthrax, glanders, plague, tularemia, Q fever, alphaviruses, orthopoxviruses, and a new chapter on brucellosis

Animal models for viral hemorrhagic fevers

Botulinum and Ricin toxins

Staphylococcal and streptococcal superantigens

As the scientific community works diligently to protect the world's population from the misuse of infectious organisms and toxins, it is imperative that researchers stay abreast of the latest techniques for biodefense research. Exploring in vivo and in vitro assays, this volume brings researchers up to date on the latest information on bacterial and viral infectious agents and biological toxins considered to pose the greatest threats to public safety. In addition, the contributors take a step toward minimizing the use of animals in further experiments by presenting documented findings that can be built upon. Book jacket.

Contents:

History of biological agents as weapons / James W. Martin

Bioterrorism and biowarfare : similarities and differences / Nelson W. Rebert

Scientific and ethical importance of animal models in biodefense research / James R. Swearengen and Arthur O. Anderson

Development and validation of animal models / Jaime B. Anderson and Kenneth Tucker

Infectious disease aerobiology : aerosol challenge methods / Chad J. Roy and Louise M. Pitt

Characterization of new and advancement of existing animal models of bacillus anthracis infection / Elizabeth K. Leffel and Louise M. Pitt

Glanders / David L. Fritz and David M. Waag

Plague / Jeffery J. Adamovicz and Patricia L. Worsham

Tularemia / Jeffery J. Adamovicz and David M. Waag

Q fever / David M. Waag and David L. Fritz

Brucellosis / Bret K. Purcell and Robert Rivard

Alphaviruses / William D. Pratt ... [et al.]

Orthopoxviruses / Peter B. Jahrling and Victoria Wahl-Jensen

Animal models for viral hemorrhagic fevers / Kelly l. Warfield and Thomas W. Geisbert

Botulinum toxins / Stephen B. Greenbaum, Jaime B. Anderson, and Frank J. Lebeda

Ricin / Stephen B. Greenbaum and Jaime B. Anderson

Staphylococcal and streptococcal superantigens : in vitro and in vivo assays / Teresa Krakauer and Bradley G. Stiles.

Notes:

Includes bibliographical references and index.

ISBN:

9781439836323

1439836329

OCLC:

755072456