Muscle aging : inclusion-body myositis and myopathies / edited by Valerie Askanas and W. King Engel.

Format:

Book

Contributor:

Askanas, Valerie.

Engel, W. King

Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.

Language:

English

Subjects (All):

Myositis.

Myositis, Inclusion Body--physiopathology.

Aging.

Medical Subjects:

Myositis, Inclusion Body--physiopathology.

Aging.

Physical Description:

xii, 250 pages, 8 unnumbered pages of color plates : illustrations ; 26 cm

Place of Publication:

Chichester, West Sussex : Wiley-Blackwell, 2012.

Summary:

For neurologists, neuroscientists, gerontologists, internists, general physicians, nurses, and physical therapists, Askanas and Engel (neurology and pathology, U. of Southern California) compile 16 articles on muscle aging and sporadic inclusion-body myositis, as well as hereditary inclusion-body myopathies. Specialists in neurology, gerontology, genetics, and other disciplines from the US, Europe, Israel, Japan, and Australia focus on various aging-associated neuromuscular disorders at the cellular and clinical levels, described through histochemical abnormalities seen in biopsies and clinical vignettes of representative aging patients. They emphasize treatable and not-yet-treatable conditions associated with aging, and stress that aging is not a valid explanation for the cause of neuromuscular symptoms. They discuss mitochondrial changes in aging, protein degradation in aging cells and mitochondria, the therapeutic implications of human muscle protein metabolism in relation to exercise and aging, and sporadic inclusion-body myositis, the molecular mechanisms involved in its pathogenesis, inflammatory and autoimmune features, clinical symptoms, physical findings, and diagnostic investigations and criteria. They address genetic aspects of hereditary inclusion-body myopathies, animal models, potential treatment, clinical features and epidemiology, the effects of mutations, and inclusion-body myopathy associated with Paget disease and frontotemporal dementia. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com)

Contents:

Ageing of the human neuromuscular system : pathological aspects / W. King Engel and Valerie Askanas

Aging of the human neuromuscular system : clinical considerations / W. King Engel and Valerie Askanas

Aging of the human neuromuscular system : patient vignettes / W. King Engel, Shalini Mahajan, Valerie Askanas

Mitochondrial changes in ageing with particular reference to muscle, and possible clinical consequences / Salvatore DiMauro, Eric Schon, Michio Hirano

Protein degradation in ageing cells and mitochondria : relevance to the neuromuscular system / Jenny Ngo and Kelvin J. A. Davies

Human muscle protein metabolism in relation to exercise and aging : potential therapeutic applications / Micah J. Drummond, Blake B. Rasmussen

Pathogenesis of sporadic inclusion-body myositis / Valerie Askanas, W. King Engel, Anna Nogalska

Inflammatory and autoimmune features of inclusion-body myositis / Marinos C. Dalakas

Sporadic inclusion-body myositis: clinical symptoms, physical findings, and diagnostic investigations / Frank L. Mastaglia

Pathologic diagnostic criteria of sporadic inclusion-body myositis and hereditary inclusion-body myopathy muscle biopsies / Valerie Askanas and W. King Engel

Function and mutations of the GNE gene leading to distal myopathy with rimmed vacuoles hereditary inclusion-body myopathy, animal models, and potential treatments / May Christine V. Malicdan, Satoru Noguchi, Ichizo Nishino

GNE myopathy (hereditary inclusion-body myopathy/distal myopathy with rimmed vacuoles): clinical features and epidemiology / Zohar Argov, Ishizo Nishino, Ikiyo Nonaka

Consequences of the hereditary inclusion-body myopathy-characteristic GNE mutations on muscle proteins in vivo and in vitro / Aldobrando Broccolini and Massimiliano Mirabella

Function and structure of VCP mutations leading to inclusion-body myopathy associated with Paget disease of bone and frontotemporal dementia / Cezary Wojcik

Clinical spectrum of VCP myopathy, Paget disease, and frontotemporal dementia : experimental models and potential treatments / Virginia Kimonis ...[et al]

Drosophila and mouse models of hereditary myopathy caused by mutations in VCP / Nisha M. Badders and J. Paul Taylor.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.

ISBN:

9781405196468

1405196467

OCLC:

741999167