Therapeutics, evidence and decision-making / Michael D. Rawlins ; foreword by Parveen J. Kumar.

Format:

Book

Author/Creator:

Rawlins, Michael D. (Michael David)

Contributor:

Royal Society of Medicine (Great Britain)

Language:

English

Subjects (All):

Evidence-based medicine.

Clinical medicine--Decision making.

Clinical medicine.

Therapeutics.

Evidence-Based Medicine--methods.

Decision Making.

Diagnostic Techniques and Procedures.

Therapeutics--methods.

Medical Subjects:

Evidence-Based Medicine--methods.

Decision Making.

Diagnostic Techniques and Procedures.

Therapeutics--methods.

Physical Description:

xiii, 230 pages : illustrations ; 24 cm

Place of Publication:

London : Hodder Arnold, 2011.

Summary:

Contemporary, thought-provoking and sometimes controversial, this book helps decision-makers use, assess and appraise the evidence that underpins daily decisions about the use of therapeutic interventions.

Base your judgements on an informed appraisal of the evidence base.

Learn how to review the nature of evidence, the strengths and weaknesses of available approaches and how to reach reliable conclusions.

Find out about the reliability of evidence and how to test it.

Answer clinical dilemmas do the benefits of the drug outweigh its harms? Is it cost effective as well as clinically effective? Is it fit for purpose?

Ultimately, good judgement is at the heart of decision making in therapeutics and therefore this key text will become a cornerstone for all physicians, pharmacists, nurses, health commissioners and purchasers and indeed anyone having to make decisions concerning evidence based therapeutics. Book jacket.

Contents:

Section 1 Introduction 1

1.1 The nature of evidence 3

1.2 Probability 8

1.3 Clinical endpoints of benefits and harms 15

1.4 Statistical expressions of benefit and harm 22

1.5 Bias and confounding 32

1.6 Systematic reviews 43

Section 2 Randomized controlled trials 61

2.1 General principles 63

2.2 Stopping rules 84

2.3 Analysis of subgroups 91

2.4 Safety 96

2.5 Generalizability 103

Section 3 Observational studies 111

3.1 General overview 113

3.2 Historical controlled trials 119

3.3 Concurrent cohort studies 127

3.4 Case-control designs 134

3.5 Databases 142

3.6 Case reports 143

Section 4 Qualitative research 155

4.1 Approaches and methods 157

4.2 Uses in the evaluation of therapeutic interventions 163

Section 5 Economic evaluation 171

5.1 General principles 173

5.2 Cost-effectiveness, cost-utility and cost-minimization analyses 187

5.3 Cost-consequences analysis 196

Section 6 Decision-making 199

6.1 For individuals 201

6.2 For populations 208.

Notes:

"RSM Books."

Includes bibliographical references and index.

ISBN:

9781853159473

1853159476

OCLC:

754842945

Publisher Number:

9786613212924