Extracellular matrix biology / edited by Richard O. Hynes, Kenneth M. Yamada.

Format:

Book

Contributor:

Hynes, Richard O.

Yamada, Kenneth M.

Series:

Cold Spring Harbor perspectives in biology

Language:

English

Subjects (All):

Extracellular matrix.

Cell interaction.

Physical Description:

viii, 397 pages : color illustrations ; 27 cm.

Place of Publication:

Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, [2012]

Summary:

In most tissues, cells are surrounded by an extracellular matrix (ECM) containing proteins such as collagen, laminin, and fibronectin. The ECM plays an important role in regulating cell function. ECM proteins bind to integrins and other cell-surface receptors, activating signaling pathways that regulate cellular morphology, adhesion, cell migration, cell proliferation, and apoptosis.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ECM composition and function, as well as alterations in the ECM that occur during development, tumorigenesis, and other disease states. The contributors examine the various ECM proteins and proteoglycans, ECM receptors such as integrins, and the signaling pathways that mediate the effects of the ECM on cells. They also describe ECM functions in specific biological contexts, including angiogenesis, hemostasis, and thrombosis.

Covering not only the biochemistry and cell biology of the ECM but also its roles in development, physiology, and pathology, this volume is an indispensable reference for cell biologists and all those interested in exploring the myriad functions of the ECM. Book jacket.

Contents:

Overview of the Matrisome- An Inventory of Extracellular Matrix Constituents and Functions / Richard O. Hynes Hynes, Richard O., Alexandra Naba Naba, Alexandra 1

Basement Membranes: Cell Scaffoldings and Signaling Platforms / Peter D. Yurchenco Yurchenco, Peter D. 17

The Collagen Family / Silvie Ricard-Blum Ricard-Blum, Silvie 45

Heparan Sulfate Proteoglycans / Stephane Sarrazin Sarrazin, Stephane, William C. Lamanna Lamanna, William C., Jeffrey D. Esko Esko, Jeffrey D. 65

The Thrombospondins / Josephine C. Adams Adams, Josephine C., Jack Lawler Lawler, Jack 99

Tenascins and the Importance of Adhesion Modulation / Ruth Chiquet-Ehrismann Chiquet-Ehrismann, Ruth, Richard P. Tucker Tucker, Richard P. 129

Fibronectins, Their Fibrillogenesis, and In Vivo Functions / Jean E. Schwarzbauer Schwarzbauer, Jean E., Douglas W. DeSimone DeSimone, Douglas W. 149

Integrin Structure, Activation, and Interactions / Iain D. Campbell Campbell, Iain D., Martin J. Humphries Humphries, Martin J. 169

Cross Talk among TGF-β Signaling Pathways, Integrins, and the Extracellular Matrix / John S. Munger Munger, John S., Dean Sheppard Sheppard, Dean 183

Molecular Architecture and Function of Matrix Adhesions / Benjamin Geiger Geiger, Benjamin, Kenneth M. Yamada Yamada, Kenneth M. 201

Genetic Analyses of Integrin Signaling / Sara A. Wickström Wickström, Sara A., Korana Radovanac Radovanac, Korana, Reinhard Fässier Fässier, Reinhard 223

Integrins and Extracellular Matrix in Mechanotransduction / Martin Alexander Schwartz Schwartz, Martin Alexander 245

Integrins in Cell Migration / Anna Huttenlocher Huttenlocher, Anna, Alan Rick Horwitz Horwitz, Alan Rick 259

Extracellular Matrix Degradation and Remodeling in Development and Disease / Pengfei Lu Lu, Pengfei, Ken Takai Takai, Ken, Valerie M. Weaver Weaver, Valerie M., Zena Werb Werb, Zena 275

Extracellular Matrix in Development: Insights from Mechanisms Conserved between Invertebrates and Vertebrates / Nicholas H. Brown Brown, Nicholas H. 299

Angiogenesis / Donald R. Senger Senger, Donald R., George E. Davis Davis, George E. 313

Extracellular Matrix: Functions in the Nervous System / Claudia S. Barros Barros, Claudia S., Santos J. Franco Franco, Santos J., Ulrica Miiller Miiller, Ulrica 333

Cell-Extracellular Matrix Interactions in Normal and Diseased Skin / Fiona M. Watt Watt, Fiona M., Hironobu Fujiwara Fujiwara, Hironobu 357

Extracellular Matrix Proteins in Hemostasis and Thrombosis / Wolfgang Bergmeier Bergmeier, Wolfgang, Richard O. Hynes Hynes, Richard O. 371.

Notes:

Includes bibliographical references and index.

ISBN:

9781936113385

1936113384

OCLC:

740623004