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Chromosome abnormalities and genetic counseling / R.J. McKinlay Gardner, Grant R. Sutherland, Lisa G. Shaffer.

Holman Biotech Commons RB155.7 .G37 2012
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Format:
Book
Author/Creator:
Gardner, R. J. M.
Contributor:
Sutherland, Grant R.
Shaffer, Lisa G.
Series:
Oxford monographs on medical genetics ; no. 61.
Oxford monographs on medical genetics ; no. 61
Language:
English
Subjects (All):
Genetic counseling.
Human chromosome abnormalities--Patients--Counseling of.
Human chromosome abnormalities.
Chromosome Aberrations.
Genetic Counseling.
Patients.
Medical Subjects:
Chromosome Aberrations.
Genetic Counseling.
Physical Description:
xiv, 634 pages : illustrations ; 27 cm.
Edition:
Fourth edition.
Place of Publication:
Oxford ; New York : Oxford University Press, [2012]
Contents:
Part 1 Basic Concepts
1 Elements of Medical Cytogenetics 3
2 Chromosome Analysis 21
3 The Origins and Consequences of Chromosome Pathology 27
4 Deriving and Using a Risk Figure 59
Part 2 Parent with a Chromosomal Abnormality
5 Autosomal Reciprocal Translocations 67
6 Sex Chromosome Translocations 112
7 Robertsonian Translocations 140
8 Centromere Fissions, Complementary Isochromosomes, Telomeric Fusions, Balancing Supernumerary Chromosomes, and Jumping Translocations 155
9 Inversions 161
10 Insertions 183
11 Autosomal Ring Chromosomes 201
12 Complex Rearrangements 212
13 Parental Sex Chromosome Aneuploidy 221
14 Parental Autosomal Aneuploidy 233
15 The Fragile X Syndromes 242
Part 3 Variants
16 Variant Chromosomes and Abnormalities of No Phenotypic Consequence 257
17 Copy Number Changes 269
Part 4 Normal Parents with a Chromosomally Abnormal Child
18 Down Syndrome, Other Full Aneuploidies, and Polyploidy 277
19 Structural Rearrangements 295
20 Chromosomal Disorders of Sex Development 333
21 Chromosome Instability Syndromes 341
Part 5 Disorders Associated with Aberrant Genomic Imprinting
22 Uniparental Disomy and Disorders of Imprinting 351
Part 6 Reproductive Failure
23 Gametogenesis and Conception, Pregnancy Loss and Infertility 377
Part 7 Prenatal Diagnosis
24 Parental Age Counseling and Screening for Fetal Trisomy 403
25 Prenatal Diagnostic Procedures 417
26 Preimplantation Genetic Diagnosis 426
27 Chromosome Abnormalities Detected at Prenatal Diagnosis 439
Part 8 Noxious Agents
28 Gonadal Cytogenetic Damage from Exposure to Extrinsic Agents 489.
Notes:
Includes bibliographical references and index.
ISBN:
9780195375336
0195375335
OCLC:
701450134

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