Molecular machines / editor, Benoît Roux.

Format:

Book

Contributor:

Roux, Benoît, 1958-

Language:

English

Subjects (All):

Molecular biology.

Cell interaction.

Cytology.

Microbiology.

Physical Description:

xii, 275 pages : illustrations (some color) ; 27 cm

Place of Publication:

Singapore : World Scientific, [2011]

Summary:

Molecular machines are complex biomolecules, proteins, nucleic acids, and carbohydrates that consume energy in order to perform specific functions. The concerted action of all those machines underlies all the activities of the living cell. To understand how such molecular machines are able to perform their function, it is necessary to identify the different moving parts and understand how they act together. Breaking new ground with these difficult problems is likely to require novel paradigms permitting a seamless integration of structural, dynamical and functional data from experiments and theory.

The goal of this volume is to provide an introduction to the world of biological molecular machines to a broad audience of students and researchers in biosciences. Each chapter is written by leading experts to cover results from cutting-edge research, while remaining broadly accessible. The volume presents the current state of knowledge for several important systems, ranging from polymerases, the ribosome, chaperonins, the chromatophore, kinases, actin and myosin, membrane transporters, and voltage-gated ion channels, thus giving students and researchers in biosciences a pedagogically integrated picture of this exciting and rapidly expanding field. Book jacket.

Contents:

Chapter 1 Molecular Behavior in Biological Cells: The Bacterial Cytoplasm as a Model System / Adrian H. Elcock Elcock, Adrian H., Andrew S. Thomas Thomas, Andrew S. 1

Chapter 2 The Light-Harvesting Apparatus in Purple Photosynthetic Bacteria: Introduction to a Quantum Biological Device / Johan Strümpfer Strümpfer, Johan, Jen Hsin Hsin, Jen, Melih Şener Şener, Melih, Danielle Chandler Chandler, Danielle, Klaus Schulten Schulten, Klaus 19

Chapter 3 DNA Polymerases: Structure, Function, and Modeling / Tamar Schlick Schlick, Tamar 49

Chapter 4 Information Processing by Nanomachines: Decoding by the Ribosome / Karissa Y. Sanbonmatsu Sanbonmatsu, Karissa Y., Scott C. Blanchard Blanchard, Scott C., Paul C. Whitford Whitford, Paul C. 67

Chapter 5 Chaperonins: The Machines Which Fold Proteins / Del Lucent Lucent, Del, Martin C Stumpe Stumpe, Martin C, Vijay S Pande Pande, Vijay S 87

Chapter 6 Muscle and Myosin / Ronald S. Rock Rock, Ronald S. 99

Chapter 7 Protein Kinases: Phosphorylation Machines / Elaine E. Thompson Thompson, Elaine E., Susan S. Taylor Taylor, Susan S., J. Andrew McCammon McCammon, J. Andrew 115

Chapter 8 Computational Studies of Na+/H+ Antiporter: Structure, Dynamics and Function / Assaf Ganoth Ganoth, Assaf, Raphael Alhadeff Alhadeff, Raphael, Isaiah T. Arkin Arkin, Isaiah T. 131

Chapter 9 Membrane Transporters: Molecular Machines Coupling Cellular Energy to Vectorial Transport Across the Membrane / Zhijian Huang Huang, Zhijian, Saher A. Shaikh Shaikh, Saher A., Po-Chao Wen Wen, Po-Chao, Giray Enkavi Enkavi, Giray, Jing Li Li, Jing, Emad Tajkhorshid Tajkhorshid, Emad 151

Chapter 10 ABC Transporters / E. P. Coll Coll, E. P., D. P. Tieleman Tieleman, D. P. 183

Chapter 11 Sodium-coupled Secondary Transporters: Insights from Structure-based Computations / Elia Zomot Zomot, Elia, Ahmet Bakan Bakan, Ahmet, Indira H. Shrivastava Shrivastava, Indira H., Jason DeChancie DeChancie, Jason, Timothy R. Lezon Lezon, Timothy R., Ivet Bahar Bahar, Ivet 199

Chapter 12 Voltage-Gated Ion Channels: The Machines Responsible for the Nerve Impulse / Benoît Roux Roux, Benoît, Francisco Bezanilla Bezanilla, Francisco 231

Chapter 13 Voltage-Gated Channels and the Heart / Jonathan R. Silva Silva, Jonathan R., Yoram Rudy Rudy, Yoram 249.

Notes:

Includes bibliographical references and index.

ISBN:

9789814343442

9814343447

OCLC:

765783309