An introduction to genetic epidemiology / edited by Lyle J. Palmer, Paul R. Burton, and George Davey Smith.

Format:

Book

Contributor:

Palmer, Lyle.

Burton, Paul R.

Davey Smith, George.

Series:

Health & society series

Language:

English

Subjects (All):

Molecular Epidemiology--methods.

Genetics, Medical--methods.

Genetic epidemiology.

Medical genetics.

Medical Subjects:

Molecular Epidemiology--methods.

Genetics, Medical--methods.

Physical Description:

ix, 230 pages : illustrations ; 25 cm.

Place of Publication:

Bristol : Policy Press, 2011.

Summary:

Palmer (biostatistics and epidemiology, U. of Toronto, Canada) et al. are joined by contributors working in genetics and epidemiology in the UK, Canada, and Australia who introduce genetic epidemiology to advanced undergraduate and graduate students in public health, epidemiology, statistics, human genetics, clinical medicine, and related disciplines, and discuss concepts and issues facing researchers attempting to map and use genetic factors underlying human disease. Chapters assume no specialist knowledge or technical background and discuss a framework for investigating genetic determinants in complex human diseases such as diabetes and asthma; the basic theory and methods of linkage and association studies; linkage analysis and family-based methods used to map genetic loci that predispose disease; association analysis and design methods for studies; and the structure of the human genome as related to single nucleotide polymorphisms and linkage disequilibrium and application to mapping disease genes. They also cover optimal study designs and characteristics; international biobanking initiatives; and the application of genetic epidemiology in population health and genomic profiling, personalized medicine, and new approaches like Mendelian randomization. The book originated in a series commissioned by the journal The Lancet in 2005. Distributed in the US by ISBS. Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)

Contents:

one Key concepts in genetic epidemiology / Paul R. Burton Burton, Paul R., Martin D.Tobin D.Tobin, Martin, John L Hopper Hopper, John L 5

2 Genetic linkage studies / M. Dawn Teare Teare, M. Dawn, Jennifer H. Barrett Barrett, Jennifer H. 39

3 Genetic association studies / Heather J. Cordell Cordell, Heather J., David G. Clayton Clayton, David G. 61

4 Mapping complex disease genes using linkage disequilibrium and genome-wide association scans / Lyle J. Palmer Palmer, Lyle J., Nicholas J. Timpson Timpson, Nicholas J., David M. Evans Evans, David M., George Davey Smith Smith, George Davey, Lon R. Cordon Cordon, Lon R. 91

5 A question of standards: what makes a good genetic association study? / Andrew T. Hattersley Hattersley, Andrew T., Mark I. McCarthy McCarthy, Mark I. 131

6 Biobanks and biobank harmonisation / Paul R. Burton Burton, Paul R., Isabel Fortier Fortier, Isabel, Mylene Deschênes Deschênes, Mylene, Anna Hansell Hansell, Anna, Lyle J. Palmer Palmer, Lyle J. 155

7 Population health aspects of genetic epidemiology: genomic profiling, personalised medicine, and Mendelian randomisation / George Davey Smith Smith, George Davey, Shah Ebrahim Ebrahim, Shah, Sarah Lewis Lewis, Sarah, Lyle J. Palmer Palmer, Lyle J. 175.

Notes:

Includes bibliographical references and index.

ISBN:

9781861348982

1861348983

9781861348975

1861348975

OCLC:

502264352