Cancer immunology and immunotherapy / Glenn Dranoff, editor.

Format:

Book

Contributor:

Dranoff, Glenn.

Series:

Current topics in microbiology and immunology ; 344.

Current topics in microbiology and immunology, 0070-217X ; v. 344

Language:

English

Subjects (All):

Cancer--Immunological aspects.

Cancer.

Cancer--Immunotherapy.

Neoplasms--immunology.

Immunotherapy.

Medical Subjects:

Neoplasms--immunology.

Immunotherapy.

Physical Description:

xiii, 304 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Heidelberg ; New York : Springer-Verlag, [2011]

Summary:

The recent FDA approval of Provenge

Immunotherapies were first explored at the turn of the twentieth century, but the crafting of potent treatments required more detailed knowledge of how the immune system responds to cancer. Advances in genetic, cellular, and biochemical technologies have begun to yield this critical information, focusing attention on immune recognition, regulation, and escape. Indeed, the dynamic interplay of these processes in the tumor microenvironment is now recognized to play a decisive role in determining disease outcome. This volume highlights the rapid progress and breadth of research in cancer immunology, and provides a framework for anticipating many more clinical successes in cancer immunotherapy. Book jacket.

Contents:

Immune infiltration in human cancer: prognostic significance and disease control / W.H. Fridman ... [et al.]

Subversion and coercion: the art of redirecting tumor immune surveillance / J.B. Mumm and M. Oft

STAT3: A target to enhance antitumor immune response / H. Lee ... [et al.]

Biology and clinical observations of regulatory T cells in cancer immunology / M.W. Teng ... [et al.]

Concepts and ways to amplify the antitumor immune response / B. Rubin and J.E. Gairin

Angiogenesis and the tumor vasculature as antitumor immune modulators: the role of vascular endothelial growth factor and endothelin / L.E. Kandalaft ... [et al.]

Adoptive cellular therapy / S.A. Grupp and C.H. June

Dendritic cell subsets as vectors and targets for improved cancer therapy / K. Palucka ... [et al.]

Identification of human idiotype-specific T cells in lymphoma and myeloma / J. Weng ... [et al.]

Modulation of CTLA-4 and GITR for Cancer Immunotherapy / F. Avogadri ... [et al.]

Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / S. Wang and L. Chen

LAG-3 in cancer immunotherapy / M.V. Goldberg and C.G. Drake

Immunologically active biomaterials for cancer therapy / O.A. Ali and D.J. Mooney

Erratum: Identification of human idiotype-specific T cells in lymphoma and myeloma / J. Weng ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

9783642141355

3642141358

OCLC:

726763702