Chemical synthetic biology / editors, Pier Luigi Luisi and Cristiano Chiarabelli.

Format:

Book

Contributor:

Luisi, P. L.

Chiarabelli, Cristiano.

Language:

English

Subjects (All):

Biomolecules--Synthesis.

Biomolecules.

Physical Description:

xi, 372 pages : illustrations ; 24 cm

Place of Publication:

Chichester, West Sussex, U.K. : Wiley, 2011.

Summary:

The term chemical synthetic biology explains editor Pier Luigi Luisi (U. of Roma, Italy)--co-editor Cristiano Chiarabelli is at the same institution-- has been coined to describe synthetic biology that "...is not based on genetic manipulation, emphasizing instead a chemical approach, one which aims at the synthesis of molecular structures and/or multi-molecular organized biological systems that do not exist in nature." Fourteen contributions--all are original except for two taken from the literature--have been brought together to explore this discipline, which Luisi describes as "...a space at the interface between chemistry, biology, and philosophy." Arrangement is in sections on nucleic acids, peptides and proteins, complex systems, and general problems (including biosafety, biosecurity, and ethical challenges). Annotation ©2011 Book News, Inc., Portland, OR (booknews.com)

Contents:

Part 1 Nucleic Acids 5

1 Searching for Nucleic Acid Alternatives / Albert Eschenmoser Eschenmoser, Albert 7

2 Never-Born RNAs: Versatile Modules for Chemical Synthetic Biology / Davide De Lucrezia Lucrezia, Davide De, Fabrizio Anella Anella, Fabrizio, Cristiano Chiarabelli Chiarabelli, Cristiano, Pier Luigi Luisi Luisi, Pier Luigi 47

3 Synthetic Biology, Tinkering Biology, and Artificial Biology: A Perspective from Chemistry / Steven A. Benner Benner, Steven A., Fei Chen Chen, Fei, Zunyi Yang Yang, Zunyi 69

4 Peptide Nucleic Acids (PNAs) as a Tool in Chemical Biology / Peter E. Nielsen Nielsen, Peter E. 107

Part 2 Peptides and Proteins 119

5 High Solubility of Random-Sequence Proteins Consisting of Five Kinds of Primitive Amino Acids / Nobuhide Doi Doi, Nobuhide, Koichi Kakukawa Kakukawa, Koichi, Yuko Oishi Oishi, Yuko, Hiroshi Yanagawa Yanagawa, Hiroshi 121

6 Experimental Approach for Early Evolution of Protein Function / Hitoshi Toyota Toyota, Hitoshi, Yuuki Hayashi Hayashi, Yuuki, Asao Yamauchi Yamauchi, Asao, Takuyo Aita Aita, Takuyo, Tetsuya Yomo Yomo, Tetsuya 139

7 Searching for de novo Totally Random Amino Acid Sequences / Cristiano Chiarabelli Chiarabelli, Cristiano, Cecilia Portela Pallares Pallares, Cecilia Portela, Anna Quintarelli Quintarelli, Anna 155

Part 3 Complex Systems 175

8 Synthetic Genetic Codes as the Basis of Synthetic Life / J. Tze-Fei Wong Wong, J. Tze-Fei, Hong Xue Xue, Hong 177

9 Toward Safe Genetically Modified Organisms through the Chemical Diversification of Nucleic Acids / Piet Herdewijn Herdewijn, Piet, Philippe Marliere Marliere, Philippe 201

10 The Minimal Ribosome / Hiroshi Yamamoto Yamamoto, Hiroshi, Markus Pech Pech, Markus, Daniela Wittek Wittek, Daniela, Isabella Moll Moll, Isabella, Knud H. Nierhaus Nierhaus, Knud H. 227

11 Semi-Synthetic Minimal Living Cells / Pasquale Stano Stano, Pasquale, Francesca Ferri Ferri, Francesca, Pier Luigi Luisi Luisi, Pier Luigi 247

Part 4 General Problems 287

12 Replicators: Components for Systems Chemistry / Olga Taran Taran, Olga, Günter von Kiedrowski Kiedrowski, Günter von 289

13 Dealing with the Outer Reaches of Synthetic Biology Biosafety, Biosecurity, IPR, and Ethical Challenges of Chemical Synthetic Biology / Markus Schmidt Schmidt, Markus, Malcolm Dando Dando, Malcolm, Anna Deplazes Deplazes, Anna 321

14 The Synthetic Approach in Biology: Epistemological Notes for Synthetic Biology / Pier Luigi Luisi Luisi, Pier Luigi 343.

Notes:

Includes bibliographical references and index.

ISBN:

9780470713976

0470713976

OCLC:

676728904