MicroRNA pathways modulate aging and neurodegenerative diseases.

Format:

Book

Thesis/Dissertation

Author/Creator:

Liu, Nan.

Contributor:

Bonini, Nancy, advisor.

University of Pennsylvania.

Language:

English

Subjects (All):

Aging.

Neurobiology.

Genetics.

Molecular biology.

0307.

0369.

0421.

0493.

Penn dissertations--Biology.

Biology--Penn dissertations.

Local Subjects:

Penn dissertations--Biology.

Biology--Penn dissertations.

0307.

0369.

0421.

0493.

Physical Description:

143 pages

Contained In:

Dissertation Abstracts International 71-01B.

System Details:

Mode of access: World Wide Web.

text file

Summary:

Aging is the most prominent risk factor for human neurodegenerative diseases. Defining a novel component that modulates aging would provide new insight into this type of age-related diseases. miRNAs are small regulatory RNAs that have been shown to regulate diverse biological processes. In this study, we first define a conserved role for miRNA pathways, in both human cells and in flies, to modulate the polyglutamine-induced neurodegenerative disease. We next identify a conserved miRNA, miR-34 as a novel component in the age-induced response. We further show that miR-34 is an integral component in regulation of aging: while lack of miR-34 triggers accelerated aging, overexpression of miR-34 protects against neurodegenerative disease-associated proteotoxicity. Taken together, our study indicates that miRNA pathways may play an intrinsic role in modulation of aging, and this role may have a profound impact on many age-related processes, including neurodegenerative diseases.

Notes:

Thesis (Ph.D. in Biology) -- University of Pennsylvania, 2009.

Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0097.

Adviser: Nancy Bonini.

Local Notes:

School code: 0175.

ISBN:

9781109582000

Access Restriction:

Restricted for use by site license.