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Magnetic resonance elastography: Technique development and application.

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Format:
Book
Thesis/Dissertation
Author/Creator:
Stein, Alan David.
Contributor:
Leigh, John S., Jr., advisor.
University of Pennsylvania.
Language:
English
Subjects (All):
Medical physics.
Diagnostic imaging.
Radiology.
Medicine.
0564.
0574.
0760.
Penn dissertations--Biochemistry.
Biochemistry--Penn dissertations.
Penn dissertations--Molecular biophysics.
Molecular biophysics--Penn dissertations.
Local Subjects:
Penn dissertations--Biochemistry.
Biochemistry--Penn dissertations.
Penn dissertations--Molecular biophysics.
Molecular biophysics--Penn dissertations.
0564.
0574.
0760.
Physical Description:
195 pages
Contained In:
Dissertation Abstracts International 59-07B.
System Details:
Mode of access: World Wide Web.
text file
Summary:
Magnetic resonance elastography is a recent advance in magnetic resonance techniques which provides a method of imaging with contrast related to mechanical tissue properties. This document reviews the current literature of the field of elastography and then discusses some unique related work in magnetic resonance elastography with experimental verification after appropriate theoretical discussion. While most recent research in the field uses a technique of periodic shear mechanical excitation coupled with phase-contrast MR techniques to estimate wave propagation velocity, this work demonstrates the feasibility of using calibrated static compressions for directly estimating elastic moduli from measured displacements. A novel device for performing mechanical excitation is introduced which uses a single piezoelectric actuator. This device is a significant enhancement over conventional electromechanical methods for several reasons including minimal magnetic field production, reproducible force generation irrespective of placement, and simplified control hardware. The ability to noninvasively explore elastic properties of tissue, both qualitatively and quantitatively, represents an exciting and potentially useful addition to the realm of magnetic resonance techniques.
Notes:
Thesis (Ph.D. in Biochemistry and Molecular biophysics) -- University of Pennsylvania, 1998.
Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3294.
Supervisor: John S. Leigh, Jr.
Local Notes:
School code: 0175.
ISBN:
9780591941265
Access Restriction:
Restricted for use by site license.

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