The biology of oligodendrocytes / edited by Patricia J. Armati and Emily K. Mathey.

Format:

Book

Contributor:

Armati, Patricia J.

Mathey, Emily K.

Language:

English

Subjects (All):

Neuroglia.

Myelination.

Oligodendroglia--physiology.

Myelin Sheath.

Medical Subjects:

Oligodendroglia--physiology.

Myelin Sheath.

Physical Description:

xiii, 289 pages : illustrations (some color) ; 24 cm

Place of Publication:

Cambridge ; New York : Cambridge University Press, 2010.

Summary:

"Traditionally, oligodendrocytes have been assumed to play a minor supporting role in the central nervous system and their importance has generally been overlooked. For the first time, this book provides a dedicated review of all of the major aspects of oligodendrocyte biology, including development, organization, genetics, and immunobiology. Later chapters emphasize the importance of this underestimated cell to the mammalian central nervous system by exploring the role of myelin synthesis and maintenance in neural disease and repair. Particular attention is paid to multiple sclerosis (MS), arguably the prime example of an acquired demyelinating disease, with detailed examinations of the current concepts regarding demyelination, oligodendroglial damage, and remyelination in MS lesions"-- Provided by publisher.

"Myelin in the peripheral nervous system (PNS) and central nervous system (CNS) is formed by Schwann cells and oligodendrocytes respectively. The myelin formed by the two glial cell types electrically insulates the axons and restricts the generation of action potentials to the nodes of Ranvier, myelin-free regions separating the myelin segments, allowing for rapid propagation of actions potentials along the axons. While there are striking overall similarities in the mechanisms of myelination and the structure and molecular composition of PNS and CNS myelin, there are also important differences between the two glial cell types"-- Provided by publisher.

Contents:

CNS oligarchs: the rise of the oligodendrocyte in a neuron-centric culture / Emily Mathey, Ariel Arthur and Patricia Armati

Comparative biology of Schwann cells and oligodendrocytes / Rudolf Martini, Janos Groh and Udo Bartsch

Control of oligodendrocyte development and myelination in the vertebrate CNS / Robert H. Miller

Molecular organization of the oligodendrocyte and myelin / Grahame Kidd and Bruce D. Trapp

The genetics of oligodendrocytes / Joseph A. Nielsen, Pierre Lau and Lynn D. Hudson

Immunobiology of the oligodendrocyte / David Kremer, Orhan Aktas, Hans-Peter Hartung and Patrick Küry

Oligodendrocytes and disease: repair, remyelination and stem cells / Neil Scolding

Glial progenitor cells and the dynamics of the oligodendrocyte and its myelin in the aged and injured CNS / Jurate Lasiene and Philip J. Horner

Oligodendroglial pathology in multiple sclerosis / Tanja Kuhlmann and Wolfgang Brück

Glutamate receptors, transporters, and periventricular leukomalacia / Tara M. Desilva and Paul A. Rosenberg.

Notes:

Includes bibliographical references (pages 202-277) and index.

ISBN:

9780521899659

0521899656

OCLC:

636911519

Online:

Cover image