Small-molecule inhibitors of protein-protein interactions / Lyubomir Vassilev, David Fry, editors.

Format:

Book

Contributor:

Vassilev, Lyubomir.

Fry, David, Dr.

Series:

Current topics in microbiology and immunology ; 348.

Current topics in microbiology and immunology, 0070-217X ; v. 348

Language:

English

Subjects (All):

Protein-protein interactions.

Enzyme inhibitors.

Physical Description:

x, 174 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Heidelberg ; New York : Springer Verlag, [2011]

Summary:

In this volume, the editors have collected the knowledgeable insights of a number of leaders in this field - researchers who have achieved success in addressing the difficult problem of inhibiting protein-protein interactions. These researchers describe their unique approaches, and share experiences, results, thoughts, and opinions. The content of the articles is rich, and in terms of scope ranges from generalized approaches to specific case studies. There are various focal points, including methodologies and the molecules themselves. Ultimately, there are numerous lessons to be taken away from this collection, and the editors hope that this snapshot of the current state of the art in developing protein-protein inhibitors not only pays tribute to the past successes, but also generates excitement about the future potential of this field

Contents:

Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions / M.J. Adler, A.G. Jamieson and A.D. Hamilton

Small-molecule inhibitors of IL-2/IL-2R: Lessons learned and applied / C.G. Wilson and M.R. Arkin

Small molecule inhibitors of the human papillomavirus E1-E2 interaction / P.W. White, A.-M. Faucher and N. Goudreau

Design of small-molecule Smac mimetics as IAP antagonists / S. Wang

Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule / B.D. Zeitlin and J.E. Nör

Small-molecule modulators of c-Myc/Max and Max/Max interactions / T. Berg

Small-molecule inhibitors of the p53-MDM2 interaction / B.T. Vu and L. Vassilev.

Notes:

Includes bibliographical references and index.

ISBN:

9783642170829

364217082X

OCLC:

690089235