Neurochemistry of sleep and wakefulness / edited by Jaime M. Monti, S.R. Pandi-Perumal, Christopher M. Sinton.

Format:

Book

Contributor:

Monti, Jaime M.

Pandi-Perumal, S. R.

Sinton, Christopher M.

Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.

Language:

English

Subjects (All):

Sleep--physiology.

Biogenic Amines--physiology.

Neurotransmitter Agents--pharmacology.

Wakefulness--physiology.

Sleep--Physiological aspects.

Sleep.

Neurochemistry.

Neuropharmacology.

Medical Subjects:

Sleep--physiology.

Biogenic Amines--physiology.

Neurotransmitter Agents--pharmacology.

Wakefulness--physiology.

Physical Description:

xxiv, 482 pages, 8 unnumbered pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

Cambridge ; New York : Cambridge University Press, 2008.

Summary:

Pharmacological approaches to our understanding of sleep have been at the forefront of sleep research for many years. Traditional techniques have included the use of pharmacological agonists and antagonists, as well as transmitter-specific lesions. These have been enhanced by the introduction of molecular genetics and the use of transgenes and targeted gene deletion. Neurochemistry of Sleep and Wakefulness is an exceptional single source of information on the role of the major mammalian neurotransmitter systems involved in the regulation of sleep and waking. With contributions from internationally recognized experts, this book clearly describes how researchers have made use of the myriad techniques in their armamentarium to characterize the role of a given neurotransmitter in the regulation of sleep and waking. Suitable for experimental and clinical pharmacologists, the book will have wider appeal to sleep researchers, psychiatrists, and any professional interested in the interdisciplinary areas of neurobiology and pharmacology.

Contents:

I. neurochemistry of the states of sleep and wakefulness

1. Neurochemistry of the preoptic hypothalamic hypnogenic mechanism / Dennis McGinty, Md. Noor Alam, Hui Gong, Melvi Methippara, Natalia Suntsova, Ruben Guzman-Marin and Ronald Szymusiak

2. Neuroanatomical and neurochemical basis of wakefulness and REM sleep systems / Ritchie E. Brown and Robert W. McCarley

3. Rapid eye movement sleep regulation by modulation of the noradrenergic system / Birendra N. Mallick, Vibha Madan and Sushil K. Jha

II. influence of neurotransmitters on sleep and wakefulness

4. Gamma-aminobutyric acid and the regulation of paradoxical, or rapid eye movement, sleep / Pierre-Herve Luppi, Damien Gervasoni, Laure Verret, Romain Goutagny, Christelle Peyron, Denise Salvert, Lucienne Leger and Patrice Fort

5. Acetylcholine modulates sleep and wakefulness: a synaptic perspective / Ralph Lydic and Helen A. Baghdoyan

6. Histamine in the control of sleep-wakefulness / Mahesh M. Thakkar and Robert W. McCarley

7. Dopamine in behavioral state control / David B. Rye and Amanda A. H. Freeman

8. Glutamate neurotransmission and sleep / Irwin Feinberg and Ian G. Campbell

9. Serotonin and sleep-wake regulation / Jaime M. Monti, Hector Jantos and Daniel Monti

III. Changing perspectives

10. Melatonin and its receptors: biological function in circadian sleep-wake regulation / Daniel P. Cardinali, S. R. Pandi-Perumal and Lennard P. Niles

11. Sleep regulatory factors / Levente Kapas and Eva Szentirmai

12. Adenosine and sleep-wake regulation / Dac Stenberg and Tarja Porkka-Heiskanen

13. Prostaglandins and the regulation of sleep and wakefulness / Osamu Hayaishi and Yoshihiro Urade

14. Neuropeptides and sleep-wake regulation / Luis de Lecea

15. Orexins in sleep and wakefulness: rodent models of narcolepsy-cataplexy / Christopher M. Sinton and Jon T. Willie

16. relevance of experimental pharmacology to currently available sleep-wake therapeutics / Rafael J. Salin-Pascual.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Gail and Warren Lieberfarb Mental Health and Neuroscience Library Resources Fund.

ISBN:

9780521864411

0521864410

OCLC:

171110395

Online:

Publisher description