Introduction to peptides and proteins / Ülo Langel ... [and others].

Format:

Book

Contributor:

Langel, Ülo.

Language:

English

Subjects (All):

Proteins--Textbooks.

Proteins.

Peptides--Textbooks.

Peptides.

Molecular Biology.

Medical Subjects:

Peptides.

Molecular Biology.

Proteins.

Genre:

Textbooks.

Physical Description:

xiv, 424 pages : illustrations ; 25 cm

Place of Publication:

Boca Raton : CRC Press/Taylor & Francis, [2010]

Summary:

Human cells produce at least 30,000 different proteins. Each has a specific function characterized by a unique sequence and native conformation that allows it to perform that function. While research in this post-genomic era has created a deluge of invaluable information, the field has lacked for an authoritative introductory text needed to inform researchers and students in all of those fields now concerned with protein research.

Introduction to Peptides and Proteins brings together some of the most respected researchers in protein science to present a remarkably coherent introduction to modern peptide and protein chemistry. The first sections of the book delve into:

Basic peptide and protein science from assembly through degradation

Traditional and emerging research methods including those used in bioinformatics and proteomics

New computational approaches and algorithms used to find patterns in the vast data collected by sequencing projects

After providing a foundation in tools and methods, the authors closely examine six protein families, including representative classes such as enzymes, cell-surface receptors, antibodies, fibrous proteins, and bioactive peptide classes. They concentrate on biochemical mechanisms and where possible indicate therapeutic or biotechnical possibilities.

Then focusing on clinical aspects, the authors investigate misfolding as found in prion diseases, miscleavage as found in Alzheimer's, and mis-sequencing as found with some cancers. Drawing from some of their own research, the authors summarize recent achievements and emerging applications. They discuss the use of proteins and peptides as drugs and the solid-phase synthesis required for drug production. They also look at the use of peptides as functional biomolecules and research tools.

No longer just the domain of biologists, many key advances in protein research started in physics labs and have involved contributions from a host of fields including statistics, drug development, genetics, and chemical spectroscopy. Introduction to Peptides and Proteins provides researchers across these fields with the thorough foundation needed to explore all the potential that protein research offers.

Contents:

Introduction to Part I / Matjaž Zorko 5

From Building Blocks to 3-D Structure

Chapter 1 Amino Acids / Matjaž Zorko 5

Chapter 2 Noncovatent Interactions / Matjaž Zorko 21

Chapter 3 Structural Organization of Proteins / Matjaž Zorko 35

Protein Biosynthesis and Posttranslational Modifications

Chapter 4 The Biosynthesis of Proteins / Matjaž Zorko 61

Chapter 5 Posttranslational Modifications / Matjaž Zorko 81

Folding of Proteins

Chapter 6 Protein Folding / Matjaž Zorko 101

Chapter 7 Intracellular Sorting of Proteins / Gunnar von Heijne 123

Protein Degradation

Chapter 8 Protein Turnover / Matjaž Zorko 137

Introduction to Part II / Astrid Grs̃lund

Chapter 9 Purification and Characterization of Proteins / Matjaž Zorko 147

Chapter 10 Crystallography and X-Ray Diffraction / Astrid Grs̃lund 159

Chapter 11 Optical Spectroscopy / Astrid Grs̃lund 167

Chapter 12 Nuclear Magnetic Resonance (NMR) / Astrid Grs̃lund 177

Chapter 13 Methods to Follow Protein Folding / Astrid Grs̃lund 189

Chapter 14 Mass Spectrometry / Astrid Grs̃lund 195

Chapter 15 Chemical Synthesis of Peptides and Proteins / Ülo Langel 199

Introduction to Part III / Tiit Land

Chapter 16 Protein Engineering and Gene Silencing / Ülo Langel 215

Chapter 17 Protein-Ligand Interactions / Ülo Langel 229

Chapter 18 Sequence Analysis and Function Prediction / Tiit Land 245

Chapter 19 Protein Structure Prediction / Tiit Land 257

Chapter 20 Proteomics / Sherry Niessen, Benjamin F. Cravatt 263

Introduction to Part IV / Ülo Langel

Chapter 21 Enzymes / Matjaž Zorko 283

Chapter 22 Nucleic Acid-Binding Proteins / Ülo Langel 313

Chapter 23 Cell Surface Receptors and Signaling / Ülo Langel 323

Chapter 24 Membrane Proteins / Gunnar von Heijne 337

Chapter 25 Antibodies / Ülo Langel 343

Chapter 26 Fibrous Proteins / Ülo Langel 355

Chapter 27 Selected Classes of Bioactive Peptides / Ülo Langel 365

Introduction to Part V / Ülo Langel, Astrid Grs̃lund

Chapter 28 Misfolding-Based Diseases / Astrid Grs̃lund 381

Chapter 29 Miscleavage-Based Diseases / Astrid Grs̃lund 389

Chapter 30 Missequence-Based Diseases / Astrid Grs̃lund 395

Chapter 31 Peptides and Proteins as Drugs / Ülo Langel 401.

Notes:

Includes bibliographical references and index.

ISBN:

9781420064124

1420064126

OCLC:

426115396