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BACE : lead target for orchestrated therapy of Alzheimer's disease / edited by Varghese John.
Holman Biotech Commons RC523 .B24 2010
Available
- Format:
- Book
- Language:
- English
- Subjects (All):
- Alzheimer's disease--Chemotherapy.
- Alzheimer's disease.
- Aspartic proteinases--Inhibitors--Therapeutic use.
- Aspartic proteinases.
- Amyloid beta-protein precursor.
- Alzheimer Disease--drug therapy.
- Amyloid Precursor Protein Secretases--pharmacology.
- Amyloid Precursor Protein Secretases--therapeutic use.
- Aspartic proteinases--Inhibitors.
- Medical Subjects:
- Alzheimer Disease--drug therapy.
- Amyloid Precursor Protein Secretases--pharmacology.
- Amyloid Precursor Protein Secretases--therapeutic use.
- Physical Description:
- xvi, 250 pages, 16 unnumbered pages of plates : illustrations (some color) ; 25 cm
- Place of Publication:
- Hoboken, N.J. : John Wiley & Sons, [2010]
- Contents:
- BACE : APP processing, and signal transduction in Alzheimer's disease / Dale E. Bredesen and Edward H. Koo
- Identification of BACE as a target in Alzheimer's disease / Robert L. Heinrikson and Sukanto Sinha
- BACE biological assays / Alfredo G. Tomasselli and Michael J. Bienkowski
- Peptidic, peptidomimetic, and HTS based BACE inhibitors / James P. Beck and Dustin J. Mergott
- Fragment-based approaches for identification of BACE inhibitors / Andreas Kuglstatter and Michael Hennig
- Structure-based drug design of BACE inhibitors : technical and practical aspects of preparation, 3-dimensional structure, and computational analysis / Felix F. Vajdos, Veerabahu Shanmugasundaram, and Alfredo G. Tomasselli
- Pharmacological models for preclinical testing : from mouse to dog to non-human primates / Jason L. Eriksen, Michael Paul Murphy, and Elizabeth Head
- Adsorption, distribution, metabolism, excretion (ADME), efficacy, and toxicology for BACE inhibitors / Ishrut Hussain and Emmanuel Demont
- Clinical trials for disease-modifying drugs such as BACE inhibitors / Henry H. Hsu
- Future strategies for development of novel BACE inhibitors : anti-APP B-site antibody and APP binding small molecule approaches for Alzheimer's disease / Beka Solomon ... [et al.].
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 9780470293423
- 047029342X
- OCLC:
- 436968376
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