Inflammatory diseases of the central nervous system / [edited by] Trevor Kilpatrick, Richard M. Ransohoff, Steven Wesselingh.

Format:

Book

Contributor:

Kilpatrick, Trevor, 1959-

Ransohoff, Richard M.

Wesselingh, Steven.

Series:

Cambridge medicine.

Cambridge medicine

Language:

English

Subjects (All):

Central nervous system--Diseases.

Central nervous system.

Inflammation.

Central Nervous System--immunology.

Central Nervous System--physiopathology.

Central Nervous System Diseases--immunology.

Neuroimmunomodulation--physiology.

Medical Subjects:

Central Nervous System--immunology.

Central Nervous System--physiopathology.

Central Nervous System Diseases--immunology.

Inflammation.

Neuroimmunomodulation--physiology.

Physical Description:

viii, 271 pages, 8 unnumbered pages of plates : illustrations (some color) ; 26 cm.

Place of Publication:

Cambridge ; New York : Cambridge University Press, 2010.

Summary:

"Interactions between the immune and nervous systems are involved in many disease processes. Modulation of inflammation can provide an important opportunity to enhance regeneration within the central nervous system. This authoritative book defines the key cellular players in mounting an inflammatory response and highlights critical factors in the target organ that influence the nature of that response and its capacity either to damage or protect the brain. Several key clinical areas are highlighted - particularly autoimmune diseases of the nervous system including multiple sclerosis, as well as microbiological and traumatic challenges; the book therefore provides both a summary of the basic science background as well as practical, clinical-friendly guidelines to management. The book will be of interest to a wide range of physicians, including neurologists, neurosurgeons, neurorehabilitationists, infectious disease physicians, and clinical neuroscientists, as well as neuroscientists and immunologists"--Provided by publisher.

Contents:

Interactions between the immune and nervous systems

Effectors and determinants of the innate and adaptive immune responses / Edgar Meinl & Hartmut Wekerle

Microglia: protective and pathogenic mediators / Bevyn Jarrott & Karina Apricơ

The role of dendritic cells in neuro-inflammation / Heather Donaghy, Edwina J. Wright & Anthony L. Cunningham

Negotiating the brain barriers: access of immune cells and pathogens into the CNS / Britta Engelghardt

Autoimmunity

Immune effector heterogeneity in multiple sclerosis and related CNS inflammatory demyelinating disorders Shaunu F. Roemer & Claudia F. Lucchinetti

Multiple sclerosis : neuro-immune cross-talk in acute and progressive stages of the disease / Martin Kerschensteiner & Reinhard Hohlfeld

CD8+ T Cell-mediated autoimmune diseases in the CNS / Lisa Walter & Matthew L. Albert

Acute disseminated encephalomyelitis: determinants and manifestations / Eppie M. Yiu & Andrew J. Kornberg

Primary angiitis of the CNS and its mimics / Tina Chadha, George F. Duna & Leonard H. Calabrese

Microbiological and traumatic challenges to the CNS

Acute viral encephalitis : role of the immune system in viral clearance from the CNS and in the generation of pathology / David N. Irani & Natalie Prow

Chronic HIV infection of the CNS: role of the immune system in virological control and the generation of pathology / Carolyn F. Orr & Bruce J. Brew

Brain inflammation during bacterial meningitis / Trine H. Mogensen & Lars Østergaard

Parasitic infections of the brain: malaria and beyond / Stephen J. Rogerson & Danny A. Milner, Jr

Role of the inflammatory process in traumatic brain damage / Cristina Morganti-Kossmann ... [et al.]

Therapy

HIV-associated neurocognitive disorders: clinical features and therapeutic challenges / Nicoline Schiess & Justin C. McArthur

Role of immunomodulation in management of infections of the CNS / Miles H. Beaman

Neuroinflammation: an emerging therapeutic target in neurological disease / Joseph M. Antony & Christopher Power.

Notes:

Includes bibliographical references and index.

ISBN:

9780521888745

0521888743

OCLC:

318872041