Lymphangiogenesis in cancer metastasis / edited by Steven A. Stacker and Marc G. Achen.

Format:

Book

Contributor:

Stacker, Steven A.

Achen, Marc G.

Series:

Cancer metastasis (Series) ; 13.

Cancer metastasis (Series)

Language:

English

Subjects (All):

Metastasis.

Neoplasm Metastasis.

Medical Subjects:

Neoplasm Metastasis.

Physical Description:

ix, 249 pages : illustrations ; 25 cm.

Place of Publication:

[New York] : Springer Verlag, [2009]

Summary:

Lymphangiogenesis and Center Metastasis introduces the new field of lymphatic vessel growth and development, and its relationship to the metastatic spread of cancer cells.

The book covers all aspects of this new field from the fundamental role that protein growth factors and their receptors play in lymphangiogenesis to the potential application of these advances to cancer diagnosis and treatment. Other clinical aspects explored include the mechanisms and importance of lymph node metastasis, the role of the lymphatics in lymphangioleiomyomatosis and Kaposi's sarcoma, and approaches for imaging lymphtics in cancer.

The book also covers the innovative approaches taken by researchers to explore new roles for lymphatic vessel biology in the context of cancer.

The information presented in this volume, which describes the revolutionary concepts of tumor lymphangiogenesis, will be of interest to all students, scientists and oncologists who are seeking to understand the complexities of tumor metastasis.

Key Features:

Presents fundamental concepts of tumor lymphangiogenesis and the molecules which control this process

Provides a comprehensive summary of current research in this ground breaking area

Provides a book which links progress in basic tumor and development biology with current and future oncology practise

Is an essential text for molecular biologists, cell biologists and oncologists seeking to understand the implications of this rapidly developing area

Contents:

1 Lymphangiogenesis in Health and Disease - an Overview / Steven A. Stacker, Marc G. Achen, Paula Haiko, Kari Alitalo 1

2 Insight Into Lymphatic Vasculature Development / Nicole C. Johnson, Guillermo Oliver 11

3 New Animal Models of Lymphangiogenesis / Benjamin M. Hogan, Stefan Schulte-Merker 27

4 Molecular Mechanisms of Lymph Node Metastasis / Matthias Rinderknecht, Michael Detmar 55

5 The Clinical Significance of Lymph-Node Metastasis / Mark B. Faries, Donald L. Morton 83

6 Clinicopathlogical Analysis of Lymphatic Vessels and of Lymphangiogenesis in Human Cancer / Ilse Van der Auwera, Peter B. Vermeulen, Luc Y. Dirix 119

7 Lymphangiogenesis and Imaging of the Lymphatics in Cancer / Baris Turkbey, Gregory Ravizzini, Peter L. Choyke, Hisataka Kobayashi 159

8 Lymphangioleiomyomatosis / Kuniaki Seyama, Toshio Kumasaka, Teruhiko Sato, Keiko Mitani 185

9 Kaposi's Sarcoma and the Lymphatics / Victoria Emuss, Chris Boshoff 211

10 Lymphatic Physiology and Function in Healthy Tissue and Cancer / Jacqueline D. Shields, Melody A. Swartz 231.

Notes:

Includes bibliographical references and index.

ISBN:

9789048122462

9048122465

OCLC:

310399993