Cannabinoids in nature and medicine / Didier M. Lambert, ed.

Format:

Book

Contributor:

Lambert, Didier M.

Language:

English

Subjects (All):

Cannabinoids.

Cannabis.

Cannabis--Therapeutic use.

Cannabinoids--therapeutic use.

Medical Subjects:

Cannabinoids--therapeutic use.

Physical Description:

xiii, 416 pages : illustrations (some color) ; 25 cm

Place of Publication:

Weinheim ; Cambridge : Wiley-VCH, [2009]

Summary:

The history and chemistry of one of mankind's oldest drugs in one comprehensive volume!

The first part of this volume focuses on the plant Cannabis sativa, its active ingredients, and the discovery of cannabinoid receptors, as well as the therapeutic applications of activating, or blocking, the receptors. Following an overview of the plant, its medicinal uses, and its preparations, further chapters cover biosynthetic pathways, pharmacological properties, cannabis-based medicine, toxicology, cannabis prohibition, and clinical situations where blocking the cannabinoid receptors might be beneficial. The second part covers the journey from humans to plants, analyzing anandamide, as well as other endocannabinoids and endocannabinoid congeners, biosynthetic pathways, current knowledge of FAAH-1, FAAH-2, monoglyceride lipase, and NAAA, concluding with new areas of research.

Contents:

Part 1 The Phytocannabinoids: The Long Journey from the Plant to the Humans

History of Cannabis and Its Preparations in Saga, Science, and Sobriquet / E. B. Russo 15

Phytocannabinoids in Cannabis sativa: Recent Studies on Biosynthetic Enzymes / F. Taura*, S. Sirikantaramas, Y. Shoyama, Y. Shoyama, S. Morimoto 51

On the Pharmacological Properties of $$9-Tetrahydro-cannabinol (THC) / B. Costa 67

Cannabidiol - Recent Advances / R. Mechoulam*, M. Peters, E. Murillo-Rodriguez, L. O. Hanuš 83

From Active Ingredients to the Discovery of the Targets: The Cannabinoid Receptors / K. Mackie 103

Medicinal Chemistry Endeavors around the Phyto-cannabinoids / E. Stern, D.M. Lambert 119

Cannabis, Pain, and Sleep: Lessons from Therapeutic Clinical Trials of Sativex®, a Cannabis-Based Medicine / E.B. Russo*, G.W. Guy, P.J. Robson 141

The Toxicology of Cannabis and Cannabis Prohibition / F. Grotenhermen 157

Human Cannabinoid Pharmacokinetics / M.A. Huestis 187

Blocking the Cannabinoid Receptors: Drug Candidates and Therapeutic Promises / G.G. Muccioli 223

Part 2 The Endocannabinoid System: The Short Journey from the Humans to the Plants

Discovery and Isolation of Anandamide and Other Endocannabinoids / L. O. Hanuš 251

Biosynthetic Pathways of the Endocannabinoid Anandamide / Y. Okamoto, J. Wang, J. Morishita, N. Ueda 267

The Multiple Pathways of Endocannabinoid Metabolism: A Zoom Out S. Vandevoorde / D.M. Lambert 283

Fatty Acid Amide Hydrolase: From Characterization to Therapeutics / G. Labar, C. Michaux 307

Monoglyceride Lipase as an Enzyme Hydrolyzing 2-Arachidonoylglycerol / S.M. Saario, J. T. Laitinen 329

The N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) / K. Tsuboi, N. Takezaki, N. Ueda 341

Genetic Polymorphisms of the Endocannabinoid System / A.G. Norrod, R.A. Puffenbarger 353

The N-Acylethanolamine-Mediated Regulatory Pathway in Plants / A. Kilaru, E.B. Blancaflor, B.J. Venables, S. Tripathy, K.S. Mysore, K.D. Chapman 365.

Notes:

Includes bibliographical references and index.

ISBN:

9783906390567

390639056X

OCLC:

228197955