Breast cancer in the post-genomic era / edited by Antonio Giordano, Nicola Normanno.

Format:

Book

Contributor:

Giordano, Antonio, MD

Normanno, Nicola.

Series:

Current clinical oncology (Totowa, N.J.)

Current clinical oncology

Language:

English

Subjects (All):

Breast--Cancer--Etiology.

Breast.

Breast--Cancer--Diagnosis.

Breast--Cancer--Treatment.

Breast--Cancer--Genetic aspects.

Breast Neoplasms--etiology.

Breast Neoplasms--genetics.

Medical Subjects:

Breast Neoplasms--etiology.

Breast Neoplasms--genetics.

Physical Description:

xi, 230 pages : illustrations (partly color) ; 24 cm.

Place of Publication:

[Dordrecht ;] [New York] : Humana Press, [2009]

Summary:

Breast Cancer is the most common tumor in women and it is the second leading cause of cancer deaths worldwide. Due to breakthroughs in gene profiling, the knowledge of the pathophysiology of the mammary gland has greatly increased over the last decade. In Breast Cancer in the Post Genomic Era, Antonio Giordano, Nicola Normanno, and a panel of international authorities in their field provide a comprehensive approach to the biology, diagnosis, prevention, and treatment of human breast carcinoma. The book provides a comprehensive approach to breast cancer, describing the use of gene profiling techniques to distinguish specific features of individual carcinomas, as well as emerging novel therapeutic approaches to treatment. Additional chapters cover the use of transgenic mice to model human breast cancer and the role of the EGF-CFC family in mammary gland development and neoplasia. Breast Cancer in the Post Genomic-Era succeeds in looking at breast cancer pathogenesis, diagnosis, and treatment under a more comprehensive light, and is a valuable resource for any Radiation or Surgical Oncologist, Cancer Biologist or Pathologist.

Contents:

1 The Genomic Basis of Breast Development and Differentiation / Jose Russo, Irma H. Russo 1

2 Mammary Glands, Stem Cells, and Breast Cancer / David L. Mack, Gilbert H. Smith, Brian W. Booth 19

3 The Genetics of Breast Cancer: Application in Clinical Practice / Antonio Russo, Valentina Agnese, Sergio Rizzo, Laura La Paglia, Viviana Bazan 39

4 Alterations in Cell Cycle Regulatory Genes in Breast Cancer / Annalisa Roberti, Marcella Macaluso, Antonio Giordano 55

5 Neuregulins in the Nucleus / Carol M. McClelland, William J. Gullick 79

6 Role of the EGF-CFC Family in Mammary Gland Development and Neoplasia / Luigi Strizzi, Kazuhide Watanabe, Mario Mancino, David S. Salomon, Caterina Bianco 87

7 Modeling Human Breast Cancer: The Use of Transgenic Mice / Rachelle L. Dillon, William J. Muller 103

8 Gene Expression Profiling in Breast Cancer: Clinical Applications / Giuseppe Russo, Antonio Giordano 123

9 TGF-β Signaling: A Novel Target for Treatment of Breast Cancer? / Jason D. Lee, Gerard C. Blobe 137

10 DNA Methylation in Breast Cancer / Moshe Szyf 151

11 Signal Transduction Inhibitors in the Treatment of Breast Cancer / Monica R. Maiello, Antonella De Luca, Marianna Gallo, Amelia D'Alessio, Pietro Carotenuto, Nicola Normanno 177

12 Integration of Target-Based Agents in Current Protocols of Breast Cancer Therapy / Maria Carmela Piccirillo, Fabiano Falasconi, Antonia Del Giudice, Gianfranco De Feo, Jane Bryce, Mario Iaccarino, Francesco Perrone, Alessandro Morabito 203.

Notes:

Includes bibliographical references and index.

ISBN:

9781603279444

160327944X

1603279458

9781603279451

OCLC:

432404931