Periodontal medicine and systems biology / edited by Brian Henderson ... [and others].

Format:

Book

Contributor:

Henderson, Brian (Professor)

Language:

English

Subjects (All):

Periodontal disease--Microbiology.

Periodontal disease.

Systems biology.

Periodontal Diseases.

Host-Pathogen Interactions.

Systems Biology.

Microbiology.

Medical Subjects:

Periodontal Diseases.

Host-Pathogen Interactions.

Systems Biology.

Physical Description:

x, 449 pages : illustrations (some color) ; 26 cm

Place of Publication:

Chichester, U.K. ; Ames, Iowa : Wiley-Blackwell, 2009.

Summary:

This book provides a systems-based approach to periodontology and offers a scientific roadmap of the interactions which can lead to periodontal disease.

The content is divided into five sections. The first section introduces the reader to the concept of systems theory and its mathematical foundation. The second section provides the reader with a current view of periodontal medicine including microbiology, molecular genetics, relationship to systemic disease and current and future therapies. Periodontitis is caused by members of the oral microbiota and the third section provides the reader with various views of the relationship of the microbiota to the host. The fourth section moves from the bacterium to the host and its immune responses to altered host: bacteria interactions. The final section deals specifically with bone destruction in periodontitis and brings the reader up-to-date with the current view of the control network that exists between mesenchymal cells such as osteoblasts, immune cells and osteoclast precursor cells that controls bone remodelling in health and disease.

The Editors

Contents:

Systems thinking in biology / Robert M. Seymour

Metagenomics and its applications to human bacterial diseases / Julian R. Marchesi

Periodontitis: a modern clinical picture / Nikos Donos and Francesco D'Aiuto

Plaque microbiology in (periodontal) health and disease / Anne D. Haffajee

Population molecular genetics of periodontitis / Marja L. Laine, Ubele van der Velden and Bruno G. Loos

Mechanisms linking periodontitis to systemic disease / Panos N. Papapanou and Jan H. Behle

The impact of diabetes-enhanced inflammation on periodontal disease and bone destruction / Dana T. Graves

The microbiota of humans / Gerald W. Tannock

The normal oral microbiota / William G. Wade

Bacterial coaggregation and periodontitis / Paul E Kolenbrander ... [et al.]

Dynamics of biofilm formation and relationship to periodontitis / Jonathan Pratten and Nicola Mordan

Quorum sensing as a means of biofilm communication / Hanjuan Shao and Donald R. Demuth

Genomics of porphyromonas gingivalis / Keisuke Nakayama

Genomics of fusobacterium nucleatum / Vinayak Kapatral

The aggregatibacter (formerly actinobacillus) actinomycetemcomitans genome-annotation, analysis and metabolic reconstruction / Fares Najar ... [et al.]

A new view of innate immunity for the twenty-first century / John Wright and Clare E. Bryant

Innate immunity and homeostasis in the periodontium / Richard P. Darveau

Antimicrobial host defence peptides in oral health and periodontitis / Deirdre A. Devine and Celine Cosseau

Control of inflammation in periodontal disease / Hatice Hasturk, Alpdogan Kantarci and Thomas E. Van Dyke

Antigen-presenting cells in chronic periodontitis / Ravi Jotwani and Christopher W. Cutler

B-cell responses in periodontitis / Suzanne E. Barbour, John G. Tew and Harvey A. Schenkein

T-cell responses in periodontitis / Gregory J. Seymour, Erica Gemmell and Kazuhisa Yamazaki

Current paradigms of osteoblast-osteoclast interactions and bacterial pathogen-induced bone resorption / Naoyuki Takahashi ... [et al.]

Bacterial osteolytic mediators / Brian Henderson and Sean P. Nair

Immune cell involvement in periodontal bone loss / Andy Y.-T. Teng

How can periodontal bone loss be stopped? / Colin R. Dunstan.

Notes:

Includes bibliographical references and index.

ISBN:

9781405122191

1405122196

OCLC:

248348307